The growth hormone-like factor produced by the tapeworm Spirometra mansonoides specifically binds receptors on cultured human lymphocytes.
J Parasitol
; 74(5): 896-8, 1988 Oct.
Article
en En
| MEDLINE
| ID: mdl-3418464
Plerocercoid larvae of the tapeworm Spirometra mansonoides produce a factor with activities similar to those of growth hormone (GH). Highly selective receptors for GH have been described on cultured human lymphocytes (IM-9 cells) and these cells have been used as a model of binding essentially restricted to human GH (hGH). We compared the displacement of [125I]hGH by hGH and partially purified plerocercoid growth factor (PGF) in assays using rabbit hepatic membranes and IM-9 cells. PGF displaced [125I]hGH from both rabbit hepatic membranes and IM-9 cells in a dose-dependent manner (r greater than 0.98). These results show that PGF specifically binds to hGH receptors on human IM-9 cells and suggest the possibility that PGF will have somatotropic activity in humans.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Spirometra
/
Receptores de Somatotropina
/
Hormona del Crecimiento
/
Linfocitos
/
Cestodos
/
Sustancias de Crecimiento
/
Péptidos y Proteínas de Señalización Intercelular
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Parasitol
Año:
1988
Tipo del documento:
Article
Pais de publicación:
Estados Unidos