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The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium.
Dabo, Bashir; Pelucchi, Claudio; Rota, Matteo; Jain, Harshonnati; Bertuccio, Paola; Bonzi, Rossella; Palli, Domenico; Ferraroni, Monica; Zhang, Zuo-Feng; Sanchez-Anguiano, Aurora; Thi-Hai Pham, Yen; Thi-Du Tran, Chi; Gia Pham, Anh; Yu, Guo-Pei; Nguyen, Tin C; Muscat, Joshua; Tsugane, Shoichiro; Hidaka, Akihisa; Hamada, Gerson S; Zaridze, David; Maximovitch, Dmitry; Kogevinas, Manolis; Fernàndez de Larrea, Nerea; Boccia, Stefania; Pastorino, Roberta; Kurtz, Robert C; Lagiou, Areti; Lagiou, Pagona; Vioque, Jesus; Camargo, M Constanza; Paula Curado, Maria; Lunet, Nuno; Boffetta, Paolo; Negri, Eva; La Vecchia, Carlo; Luu, Hung N.
Afiliación
  • Dabo B; College of Public Health, University of South Florida, Tampa, Florida, USA.
  • Pelucchi C; Department of Clinical Sciences and Community Health, University of Milan, Milan.
  • Rota M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
  • Jain H; Department of Information Systems and Decision Sciences (ISDS), Muma College of Business, University of South Florida, Tampa, Florida, USA.
  • Bertuccio P; Department of Biomedical and Clinical Sciences, University of Milan, Milan.
  • Bonzi R; Department of Clinical Sciences and Community Health, University of Milan, Milan.
  • Palli D; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
  • Ferraroni M; Department of Clinical Sciences and Community Health, University of Milan, Milan.
  • Zhang ZF; Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California, USA.
  • Sanchez-Anguiano A; College of Public Health, University of South Florida, Tampa, Florida, USA.
  • Thi-Hai Pham Y; Department of Rehabilitation, Vinmec Hospital Times City, Vinmec Healthcare System.
  • Thi-Du Tran C; Vietnam Colorectal Cancer and Polyps Research Program, Vinmec Healthcare System.
  • Gia Pham A; Department of Surgical Oncology, Viet-Duc University Hospital, Hanoi, Vietnam.
  • Yu GP; Medical Informatics Center, Peking University, Peking, China.
  • Nguyen TC; Department of Computer Sciences and Engineering, University of Nevada-Reno, Reno, Nevada.
  • Muscat J; Department of Public Health Sciences, Tobacco Center of Regulatory Science, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Tsugane S; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Japan.
  • Hidaka A; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Japan.
  • Hamada GS; Nikkei Disease Prevention Center, São Paulo, Brazil.
  • Zaridze D; Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
  • Maximovitch D; Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
  • Kogevinas M; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid.
  • Fernàndez de Larrea N; ISGlobal.
  • Boccia S; IMIM (Hospital del Mar Medical Research Institute).
  • Pastorino R; Universitat Pompeu Fabra (UPF), Barcelona.
  • Kurtz RC; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid.
  • Lagiou A; Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Carlos III Health Institute, Madrid, Spain.
  • Lagiou P; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore.
  • Vioque J; Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
  • Camargo MC; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore.
  • Paula Curado M; Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.
  • Lunet N; Department of Public and Community Health, School of Health Sciences, University of West Attica.
  • Boffetta P; Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Negri E; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • La Vecchia C; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid.
  • Luu HN; Department of Public Health, Miguel Hernandez University, FISABIO-ISABIAL, Campus San Juan, Alicante, Spain.
Eur J Cancer Prev ; 31(3): 260-269, 2022 05 01.
Article en En | MEDLINE | ID: mdl-34183534
BACKGROUND: Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. OBJECTIVE: To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. METHODS: We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. RESULTS: We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. CONCLUSION: This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Helicobacter pylori / Infecciones por Helicobacter / Diabetes Mellitus Tipo 2 Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Eur J Cancer Prev Asunto de la revista: NEOPLASIAS / SAUDE PUBLICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Helicobacter pylori / Infecciones por Helicobacter / Diabetes Mellitus Tipo 2 Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Eur J Cancer Prev Asunto de la revista: NEOPLASIAS / SAUDE PUBLICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido