Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity.

Tosca, Elena M; Bartolucci, Roberta; Magni, Paolo; Poggesi, Italo

Tosca, Elena M; Bartolucci, Roberta; Magni, Paolo; Poggesi, Italo.

Afiliación

Tosca EM; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Bartolucci R; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Magni P; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Poggesi I; Clinical Pharmacology & Pharmacometrics, Janssen Research & Development, Beerse, Belgium.

Expert Opin Drug Discov ; 16(11): 1365-1390, 2021 11.

Article en En | MEDLINE | ID: mdl-34181496

Asunto(s)

Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos; Modelos Biológicos; Descubrimiento de Drogas; Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/etiología; Humanos; Hígado; Aprendizaje Automático

Palabras clave

Pharmacokinetic-Pharmacodynamic models; Safety; attrition-rate; cardiovascular toxicity; computational approaches; drug-induced liver toxicity; hematological toxicity; immunotoxicity; quantitative system pharmacology models; tolerability

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Modelos Biológicos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Expert Opin Drug Discov Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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