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Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses.
Pelissier Vatter, Fanny A; Cioffi, Michele; Hanna, Samer J; Castarede, Ines; Caielli, Simone; Pascual, Virginia; Matei, Irina; Lyden, David.
Afiliación
  • Pelissier Vatter FA; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
  • Cioffi M; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
  • Hanna SJ; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
  • Castarede I; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
  • Caielli S; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Pascual V; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY.
  • Matei I; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY.
  • Lyden D; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
J Exp Med ; 218(8)2021 08 02.
Article en En | MEDLINE | ID: mdl-34180950
Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ physiology in both health and disease. Under normal physiological conditions, immune cell-derived EVPs participate in immune responses by regulating innate and adaptive immune responses. EVPs play a major role in antigen presentation and immune activation. On the other hand, immune cell-derived EVPs exert immunosuppressive and regulatory effects. Consequently, EVPs may contribute to pathological conditions, such as autoimmune and inflammatory diseases, graft rejection, and cancer progression and metastasis. Here, we provide an overview of the role of EVPs in immune homeostasis and pathophysiology, with a particular focus on their contribution to innate and adaptive immunity and their potential use for immunotherapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comunicación Celular / Micropartículas Derivadas de Células / Inmunidad Adaptativa / Vesículas Extracelulares / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: J Exp Med Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comunicación Celular / Micropartículas Derivadas de Células / Inmunidad Adaptativa / Vesículas Extracelulares / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: J Exp Med Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos