Your browser doesn't support javascript.
loading
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention.
Shirbhate, Ekta; Pandey, Jaiprakash; Patel, Vijay K; Kamal, Mehnaz; Jawaid, Talha; Gorain, Bapi; Kesharwani, Prashant; Rajak, Harish.
Afiliación
  • Shirbhate E; Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, Chhattisgarh, 495 009, India.
  • Pandey J; Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, Chhattisgarh, 495 009, India.
  • Patel VK; Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, Chhattisgarh, 495 009, India.
  • Kamal M; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box No. 173, Al-Kharj, 11942, Kingdom of Saudi Arabia.
  • Jawaid T; Department of Pharmacology, College of Medicine, Al Imam Bin Saud Islamic University, Riyadh, 13314, Kingdom of Saudi Arabia.
  • Gorain B; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.
  • Kesharwani P; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. prashantdops@gmail.com.
  • Rajak H; Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, Chhattisgarh, 495 009, India. harishdops@yahoo.co.in.
Pharmacol Rep ; 73(6): 1539-1550, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34176080
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza