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Immunological features and factors associated with mucocutaneous bullous pemphigoid - a retrospective cohort study.
Ständer, Sascha; Schmidt, Enno; Zillikens, Detlef; Ludwig, Ralf J; Kridin, Khalaf.
Afiliación
  • Ständer S; Department of Dermatology, University of Lübeck, Lübeck, Germany.
  • Schmidt E; Department of Dermatology, University of Lübeck, Lübeck, Germany.
  • Zillikens D; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
  • Ludwig RJ; Department of Dermatology, University of Lübeck, Lübeck, Germany.
  • Kridin K; Department of Dermatology, University of Lübeck, Lübeck, Germany.
J Dtsch Dermatol Ges ; 19(9): 1289-1295, 2021 09.
Article en En | MEDLINE | ID: mdl-34164921
BACKGROUND AND OBJECTIVES: The features of bullous pemphigoid (BP) patients presenting with mucosal lesions are not established. We aimed to elucidate the clinical and immunological features of BP patients with mucosal involvement, and to identify factors associated with mucosal lesions. PATIENTS AND METHODS: A retrospective study encompassing all consecutive patients diagnosed with BP throughout the years 2009-2019 in a tertiary referral center. RESULTS: The study encompassed 273 patients with BP, of whom 31 (11.4 %) presented with mucosal lesions. The oral mucosa was the most frequently affected mucosal surface (71.0 %), followed by the genital (25.8 %) and the nasal (22.6 %) mucosae. Relative to other patients with BP, patients with mucosal involvement had a more prominent palmoplantar involvement (67.7 % vs. 37.2 %; P = 0.001); lower seropositivity rate (18.2 % vs. 54.2 %; P = 0.027) and lower levels (29.3 ± 64.5 vs. 129.5 ± 304.4 U/ml; P = 0.016) of anti-BP230 autoantibodies; and decreased peripheral eosinophil counts (760.0 ± 638.6 vs. 1296.3 ± 1013.7; P < 0.001). Absence of anti-BP230 autoantibodies (OR, 5.32; 95 % CI, 1.07-26.32; P = 0.026) and lack of peripheral eosinophilia (OR, 4.31; 95 % CI, 1.14-16.39; P = 0.021) were associated with the presence of mucosal involvement in BP. CONCLUSIONS: Mucosal involvement is present in a notable subgroup of patients with BP and is associated with the absence of both anti-BP230 antibodies and peripheral eosinophilia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penfigoide Ampolloso / Eosinofilia Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Dtsch Dermatol Ges Asunto de la revista: DERMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penfigoide Ampolloso / Eosinofilia Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Dtsch Dermatol Ges Asunto de la revista: DERMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania