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Disposable photonics for cost-effective clinical bioassays: application to COVID-19 antibody testing.
Cognetti, John S; Steiner, Daniel J; Abedin, Minhaz; Bryan, Michael R; Shanahan, Conor; Tokranova, Natalya; Young, Ethan; Klose, Alanna M; Zavriyev, Alexander; Judy, Nicholas; Piorek, Brian; Meinhart, Carl; Jakubowicz, Raymond; Warren, Harold; Cady, Nathaniel C; Miller, Benjamin L.
Afiliación
  • Cognetti JS; Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA. Benjamin_miller@urmc.rochester.edu.
  • Steiner DJ; Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, USA.
  • Abedin M; College of Nanoscale Science and Engineering, SUNY Polytechnic, Albany, New York, USA.
  • Bryan MR; Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, USA.
  • Shanahan C; Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA. Benjamin_miller@urmc.rochester.edu.
  • Tokranova N; College of Nanoscale Science and Engineering, SUNY Polytechnic, Albany, New York, USA.
  • Young E; Ortho-Clinical Diagnostics, Rochester, New York, USA.
  • Klose AM; Department of Dermatology, University of Rochester, Rochester, New York, USA.
  • Zavriyev A; Institute of Optics, University of Rochester, Rochester, New York, USA.
  • Judy N; Department of Mechanical Engineering, University of California at Santa Barbara, Santa Barbara, California, USA.
  • Piorek B; Department of Mechanical Engineering, University of California at Santa Barbara, Santa Barbara, California, USA.
  • Meinhart C; Department of Mechanical Engineering, University of California at Santa Barbara, Santa Barbara, California, USA.
  • Jakubowicz R; Ortho-Clinical Diagnostics, Rochester, New York, USA.
  • Warren H; Ortho-Clinical Diagnostics, Rochester, New York, USA.
  • Cady NC; College of Nanoscale Science and Engineering, SUNY Polytechnic, Albany, New York, USA.
  • Miller BL; Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA. Benjamin_miller@urmc.rochester.edu and Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, USA and Institute of Optics, University of Rochester, Rochester, New York, USA and
Lab Chip ; 21(15): 2913-2921, 2021 08 07.
Article en En | MEDLINE | ID: mdl-34160511
Decades of research have shown that biosensors using photonic circuits fabricated using CMOS processes can be highly sensitive, selective, and quantitative. Unfortunately, the cost of these sensors combined with the complexity of sample handling systems has limited the use of such sensors in clinical diagnostics. We present a new "disposable photonics" sensor platform in which rice-sized (1 × 4 mm) silicon nitride ring resonator sensor chips are paired with plastic micropillar fluidic cards for sample handling and optical detection. We demonstrate the utility of the platform in the context of detecting human antibodies to SARS-CoV-2, both in convalescent COVID-19 patients and for subjects undergoing vaccination. Given its ability to provide quantitative data on human samples in a simple, low-cost single-use format, we anticipate that this platform will find broad utility in clinical diagnostics for a broad range of assays.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óptica y Fotónica / COVID-19 Tipo de estudio: Health_economic_evaluation Límite: Humans Idioma: En Revista: Lab Chip Asunto de la revista: BIOTECNOLOGIA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óptica y Fotónica / COVID-19 Tipo de estudio: Health_economic_evaluation Límite: Humans Idioma: En Revista: Lab Chip Asunto de la revista: BIOTECNOLOGIA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido