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Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder.
Chen, Yunhui; Ou, Yangpan; Lv, Dan; Ma, Jidong; Zhan, Chuang; Yang, Ru; Jia, Cuicui; Shang, Tinghuizi; Sun, Lei; Wang, Yuhua; Sun, Zhenghai; Zhang, Guangfeng; Wang, Xiaoping; Guo, Wenbin; Li, Ping.
Afiliación
  • Chen Y; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Ou Y; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Lv D; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Ma J; Department of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, Heilongjiang 150050, China.
  • Zhan C; Department of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, Heilongjiang 150050, China.
  • Yang R; Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Jia C; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Shang T; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Sun L; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Wang Y; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Sun Z; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
  • Zhang G; Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, China.
  • Wang X; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Guo W; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
  • Li P; Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Neural Plast ; 2021: 9966378, 2021.
Article en En | MEDLINE | ID: mdl-34158811
Background: Patients with obsessive-compulsive disorder (OCD) experience deficiencies in reward processing. The investigation of the reward circuit and its essential connectivity may further clarify the pathogenesis of OCD. Methods: The current research was designed to analyze the nucleus accumbens (NAc) functional connectivity at rest in medicine-free patients with OCD. Forty medication-free patients and 38 gender-, education-, and age-matched healthy controls (HCs) were recruited for resting-state functional magnetic resonance imaging. Seed-based functional connectivity (FC) was used to analyze the data. LIBSVM (library for support vector machines) was designed to identify whether altered FC could be applied to differentiate OCD. Results: Patients with OCD showed remarkably decreased FC values between the left NAc and the bilateral orbitofrontal cortex (OFC) and bilateral medial prefrontal cortex (MPFC) and between the right NAc and the left OFC at rest in the reward circuit. Moreover, decreased left NAc-bilateral MPFC connectivity can be deemed as a potential biomarker to differentiate OCD from HCs with a sensitivity of 80.00% and a specificity of 76.32%. Conclusion: The current results emphasize the importance of the reward circuit in the pathogenesis of OCD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Conectoma / Núcleo Accumbens / Trastorno Obsesivo Compulsivo Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Neural Plast Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Conectoma / Núcleo Accumbens / Trastorno Obsesivo Compulsivo Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Neural Plast Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos