The Carbapenemase BKC-1 from Klebsiella pneumoniae Is Adapted for Translocation by Both the Tat and Sec Translocons.

Bharathwaj, Manasa; Webb, Chaille T; Vadlamani, Grishma; Stubenrauch, Christopher J; Palmer, Tracy; Lithgow, Trevor

Bharathwaj, Manasa; Webb, Chaille T; Vadlamani, Grishma; Stubenrauch, Christopher J; Palmer, Tracy; Lithgow, Trevor.

Afiliación

Bharathwaj M; Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Webb CT; Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Vadlamani G; Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Stubenrauch CJ; The University of Western Australia, School of Molecular Sciences & The ARC Centre of Excellence in Plant Energy Biology, Crawley, Western Australia, Australia.
Palmer T; Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
Lithgow T; Microbes in Health and Disease, Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

mBio ; 12(3): e0130221, 2021 06 29.

Article en En | MEDLINE | ID: mdl-34154411

Asunto(s)

Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Productos del Gen tat/genética; Klebsiella pneumoniae/genética; Canales de Translocación SEC/genética; beta-Lactamasas/genética; beta-Lactamasas/metabolismo; Antibacterianos/farmacología; Transporte Biológico; Escherichia coli/genética; Humanos; Infecciones por Klebsiella/microbiología; Klebsiella pneumoniae/efectos de los fármacos; Klebsiella pneumoniae/enzimología; Pruebas de Sensibilidad Microbiana; Periplasma/metabolismo; beta-Lactamas/farmacología

Palabras clave

Tat pathway; antimicrobial resistance; beta-lactamases; evolution; periplasm; protein secretion; signal peptide; ß-lactamase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Productos del Gen tat / Canales de Translocación SEC / Klebsiella pneumoniae Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: MBio Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

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