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The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
Otava, Tomás; Sála, Michal; Li, Fengling; Fanfrlík, Jindrich; Devkota, Kanchan; Perveen, Sumera; Chau, Irene; Pakarian, Paknoosh; Hobza, Pavel; Vedadi, Masoud; Boura, Evzen; Nencka, Radim.
Afiliación
  • Otava T; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, v.v.i., Gilead Sciences Research Centre at the IOCB Prague, Flemingovo nam. 2., 166 10 Prague 6, Czech Republic.
  • Sála M; Faculty of Food and Biochemical Technology, University of Chemistry and Technology, 166 28, Prague 6, Czech Republic.
  • Li F; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, v.v.i., Gilead Sciences Research Centre at the IOCB Prague, Flemingovo nam. 2., 166 10 Prague 6, Czech Republic.
  • Devkota K; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, v.v.i., Gilead Sciences Research Centre at the IOCB Prague, Flemingovo nam. 2., 166 10 Prague 6, Czech Republic.
  • Vedadi M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, v.v.i., Gilead Sciences Research Centre at the IOCB Prague, Flemingovo nam. 2., 166 10 Prague 6, Czech Republic.
  • Nencka R; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, v.v.i., Gilead Sciences Research Centre at the IOCB Prague, Flemingovo nam. 2., 166 10 Prague 6, Czech Republic.
ACS Infect Dis ; 7(8): 2214-2220, 2021 08 13.
Article en En | MEDLINE | ID: mdl-34152728
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Metiltransferasas Límite: Humans Idioma: En Revista: ACS Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Metiltransferasas Límite: Humans Idioma: En Revista: ACS Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos