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How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?
Adler, Christina Jane; Cao, Kim-Anh Lê; Hughes, Toby; Kumar, Piyush; Austin, Christine.
Afiliación
  • Adler CJ; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Cao KL; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Hughes T; Melbourne Integrative Genomics, School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria, Australia.
  • Kumar P; Adelaide Dental School, The University of Adelaide, Adelaide, South Australia, Australia.
  • Austin C; Department of Environmental Medicine and Public Health, Mount Sinai School of Medicine, New York, New York, USA.
Bioessays ; 43(9): e2000314, 2021 09.
Article en En | MEDLINE | ID: mdl-34151446
The first 1000 days of life, from conception to 2 years, are a critical window for the influence of environmental exposures on the assembly of the oral microbiome, which is the precursor to dental caries (decay), one of the most prevalent microbially induced disorders worldwide. While it is known that the human microbiome is susceptible to environmental exposures, there is limited understanding of the impact of prenatal and early childhood exposures on the oral microbiome trajectory and oral health. A barrier has been the lack of technology to directly measure the foetal "exposome", which includes nutritional and toxic exposures crossing the placenta. Another barrier has been the lack of statistical methods to account for the high dimensional data generated by-omic assays. Through identifying which early life exposures influence the oral microbiome and modify oral health, these findings can be translated into interventions to reduce dental decay prevalence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caries Dental / Microbiota / Exposoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Pregnancy Idioma: En Revista: Bioessays Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caries Dental / Microbiota / Exposoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Pregnancy Idioma: En Revista: Bioessays Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos