Your browser doesn't support javascript.
loading
Quantitative analysis of mitochondrial ATP synthesis.
Randall, E Benjamin; Hock, Marcus; Lopez, Rachel; Marzban, Bahador; Marshall, Collin; Beard, Daniel A.
Afiliación
  • Randall EB; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Hock M; Department of Bioengineering, University of California at San Diego, San Diego, 92093, CA, USA.
  • Lopez R; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Marzban B; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Marshall C; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA.
  • Beard DA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA. Electronic address: beardda@umich.edu.
Math Biosci ; 340: 108646, 2021 10.
Article en En | MEDLINE | ID: mdl-34146585
We present a computational framework for analyzing and simulating mitochondrial ATP synthesis using basic thermodynamic and kinetic principles. The framework invokes detailed descriptions of the thermodynamic driving forces associated with the processes of the electron transport chain, mitochondrial ATP synthetase, and phosphate and adenine nucleotide transporters. Assembling models of these discrete processes into an integrated model of mitochondrial ATP synthesis, we illustrate how to analyze and simulate in vitro respirometry experiments and how models identified from in vitro experimental data effectively explain cardiac respiratory control in vivo. Computer codes for these analyses are embedded as Python scripts in a Jupyter Book to facilitate easy adoption and modification of the concepts developed here. This accessible framework may also prove useful in supporting educational applications. All source codes are available on at https://beards-lab.github.io/QAMAS_book/.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Mitocondrias / Modelos Biológicos Idioma: En Revista: Math Biosci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Mitocondrias / Modelos Biológicos Idioma: En Revista: Math Biosci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos