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Mentha aquatica L. aerial parts: in vitro anti-proliferative evaluation on human tumour and non-tumour cell lines.
de Souza, Luciana Bitencourt; Tinti, Sirlene Valerio; Sousa, Ilza Maria de Oliveira; Montanari, Ilio; da Costa, José Luiz; de Carvalho, João Ernesto; Foglio, Mary Ann; Ruiz, Ana Lucia Tasca Gois.
Afiliación
  • de Souza LB; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas - UNICAMP, Paulínia, Brazil.
  • Tinti SV; Postgraduate Program in Dentistry, Piracicaba Dental School, FOP, University of Campinas - UNICAMP, Piracicaba, Brazil.
  • Sousa IMO; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas - UNICAMP, Paulínia, Brazil.
  • Montanari I; Medical Science Department, FCM, University of Campinas - UNICAMP, Campinas, Brazil.
  • da Costa JL; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas - UNICAMP, Paulínia, Brazil.
  • de Carvalho JE; LTA, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil.
  • Foglio MA; LAFTEx, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil.
  • Ruiz ALTG; LAFTEx, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil.
Nat Prod Res ; 36(12): 3117-3123, 2022 Jun.
Article en En | MEDLINE | ID: mdl-34142601
Bearing in mind the several medicinal properties of Mentha genus, this work aimed to evaluate the anti-proliferative potential of the ethanolic extract (EE) and fractions from M. aquatica L aerial parts. Using the anti-proliferative protocol developed by the NCI/USA, four fractions (F2 - F4 and F6) obtained from EE showed promising anti-proliferative profile against a panel of human tumor and non-tumor cell lines. After 24-h exposure, F2 (0.25 µg/mL) showed potent and irreversible anti-proliferative effect without inducing cell cycle arrest in both NCI-H460 and MCF-7 cells, without (anti) estrogenic activity. These effects were lost after storage of F2 diluted in dimethyl sulfoxide at -80 °C during 2 weeks. Analysis by gas chromatography coupled to mass detection evidenced some chemical changes induced by F2 storage in solution. The present study demonstrated the anti-proliferative effect of M. aquatica. Further studies are necessary to determine better storage conditions to enhance F2 stability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mentha Límite: Humans Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mentha Límite: Humans Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido