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Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China.
Zhang, Yajie; Qiao, Lin; Yao, Jinxiu; Yu, Nan; Mu, Xiaoping; Huang, Shengqi; Hu, Bo; Li, Weixuan; Qiu, Feng; Zeng, Fangyin; Chen, Cong; Zhou, Yuqiu; Zhang, Bashan; Cai, Tian; Wang, Weijia; Wu, Xianjin; Zhou, Yiwen; Wang, Guochang; Situ, Bo; Lan, Shuling; Li, Na; Li, Xiu; Li, Zihua; Li, Xin; Wang, Congrong; Yang, Chao; Feng, Pingfeng; Wang, Hongxia; Zhu, Sijing; Xiong, Yufeng; Luo, Min; Shen, Wenjuan; Hu, Xiumei; Zheng, Lei.
Afiliación
  • Zhang Y; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Qiao L; Guangdong 999 Brain Hospital, Guangzhou, China.
  • Yao J; Yangjiang People's Hospital, Yangjiang, China.
  • Yu N; Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Mu X; Guangdong Women and Children Hospital, Guangzhou, China.
  • Huang S; Jiangmen Central Hospital, Jiangmen, China.
  • Hu B; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Li W; The First People's Hospital of Foshan, Foshan, China.
  • Qiu F; Nanhai Hospital, Southern Medical University, Foshan, China.
  • Zeng F; The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China.
  • Chen C; Central People's Hospital of Zhanjiang, Zhanjiang, China.
  • Zhou Y; Zhuhai Maternal and Child Health Hospital, Zhuhai, China.
  • Zhang B; Dongguan People's Hospital, Dongguan, China.
  • Cai T; Nanhai District People's Hospital of Foshan, Foshan, China.
  • Wang W; Zhongshan People's Hospital, Zhongshan, China.
  • Wu X; Central People's Hospital of Huizhou, Huizhou, China.
  • Zhou Y; Shenzhen Hospital of Southern Medical University, Shenzhen, China.
  • Wang G; School of Economics, Jinan University, Guangdong, Guangzhou, China.
  • Situ B; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Lan S; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li N; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li X; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li Z; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li X; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Wang C; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Yang C; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Feng P; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Wang H; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Zhu S; Nanfang College of Sun Yat-Sen University, Guangdong, Guangzhou, China.
  • Xiong Y; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Luo M; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Shen W; The Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangdong, China.
  • Hu X; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. hxxm19860108@163.com.
  • Zheng L; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. nfyyzhenglei@smu.edu.cn.
BMC Pediatr ; 21(1): 284, 2021 06 17.
Article en En | MEDLINE | ID: mdl-34140022
BACKGROUND: Acute respiratory infections (ARI) cause considerable morbidity and mortality worldwide, especially in children. Unfortunately, there are limited multi-center data on common viral respiratory infections in south China. METHODS: A total of 4403 nasal swabs were collected from children in 10 cities in Guangdong, China in 2019. Seven respiratory viruses, influenza A virus (IFA), influenza B virus (IFB), respiratory syncytial virus (RSV), adenoviruses (ADV) and parainfluenza virus types 1-3 (PIV1, PIV2 and PIV3), were detected by direct immunofluorescence antibody assay. The personal information and clinical characteristics were recorded and analyzed. RESULTS: The results showed that at least one virus was detected in 1099 (24.96 %) samples. The detection rates of RSV, IFA, ADV, PIV3, PIV1 and PIV2 were 7.13 % (314/4403), 5.31 % (234/4403), 4.02 % (177/4403), 3.04 % (134/4403), 1.70 % (75/4403) and 1.16 % (51/4403), respectively. The detection rate of RSV was highest in 0-6-month-old children at 18.18 % (106/583), while the detection rate of IFA was highest in 12-18-year-old children at 20.48 % (17/83). The total detection rates in winter and spring were 35.67 % (219/614) and 34.56 % (403/1166), higher than those in summer, 17.41 % (284/1631), and autumn, 19.46 % (193/992). CONCLUSIONS: RSV and IFA were the main respiratory viruses in children. With increasing age the detection rate of RSV decreased in children, but the trends for the detection rates of IFA and IFB were the opposite. This study provided the viral etiology and epidemiology of pediatric patients with ARI in Guangdong, China.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Virus / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adolescent / Child / Humans / Infant / Newborn País/Región como asunto: Asia Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Virus / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adolescent / Child / Humans / Infant / Newborn País/Región como asunto: Asia Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido