Naturally circulating pertactin-deficient <i>Bordetella pertussis</i> strains induce distinct gene expression and inflammatory signatures in human dendritic cells.

Kroes, Michiel M; Miranda-Bedate, Alberto; Hovingh, Elise S; Jacobi, Ronald; Schot, Corrie; Pupo, Elder; Raeven, René H M; van der Ark, Arno A J; van Putten, Jos P M; de Wit, Jelle; Mariman, Rob; Pinelli, Elena

Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells.

Kroes, Michiel M; Miranda-Bedate, Alberto; Hovingh, Elise S; Jacobi, Ronald; Schot, Corrie; Pupo, Elder; Raeven, René H M; van der Ark, Arno A J; van Putten, Jos P M; de Wit, Jelle; Mariman, Rob; Pinelli, Elena.

Afiliación

Kroes MM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Miranda-Bedate A; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Hovingh ES; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Jacobi R; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Schot C; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Pupo E; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Raeven RHM; Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands.
van der Ark AAJ; Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands.
van Putten JPM; Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands.
de Wit J; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Mariman R; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Pinelli E; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.

Emerg Microbes Infect ; 10(1): 1358-1368, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34132167

Asunto(s)

Proteínas de la Membrana Bacteriana Externa/genética; Bordetella pertussis/inmunología; Células Dendríticas/inmunología; Transcriptoma; Factores de Virulencia de Bordetella/genética; Adaptación Biológica; Proteínas de la Membrana Bacteriana Externa/metabolismo; Bordetella pertussis/genética; Bordetella pertussis/metabolismo; Bordetella pertussis/patogenicidad; Citocinas/genética; Citocinas/metabolismo; Células Dendríticas/metabolismo; Perfilación de la Expresión Génica; Interacciones Huésped-Patógeno; Humanos; Inflamación; Vacuna contra la Tos Ferina/inmunología; Receptor Toll-Like 2/inmunología; Receptor Toll-Like 4/inmunología; Factores de Virulencia de Bordetella/metabolismo; Tos Ferina/microbiología

Palabras clave

Pathogen adaptation; RNAseq; dendritic cell; human; innate immunity; pertactin; proteomics; transcriptomics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de la Membrana Bacteriana Externa / Bordetella pertussis / Células Dendríticas / Factores de Virulencia de Bordetella / Transcriptoma Límite: Humans Idioma: En Revista: Emerg Microbes Infect Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos

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