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Relationships between serum levels of lactate dehydrogenase and neurological outcomes of patients who underwent targeted temperature management after out-of-hospital cardiac arrest.
You, Yeon Ho; In, Yong Nam; Park, Jung Soo; Yoo, Insool; Kim, Seung Whan; Lee, Jinwoong; Ryu, Seung; Min, Jin Hong; Jeong, Won Joon; Cho, Yong Chul; Oh, Se Kwang; Ahn, Hong Joon; Kang, Chang Shin; Lee, Byung Kook; Lee, Dong Hun; Lee, Dong Hoon; Yu, Gyeong Gyu.
Afiliación
  • You YH; Department of Emergency Medicine, Chungnam National University Hospital.
  • In YN; Department of Emergency Medicine, College of Medicine, Chungnam National University, Jung-gu, Daejeon.
  • Park JS; Department of Emergency Medicine, Chungnam National University Sejong Hospital, Sejong.
  • Yoo I; Department of Emergency Medicine, Chungnam National University Hospital.
  • Kim SW; Department of Emergency Medicine, College of Medicine, Chungnam National University, Jung-gu, Daejeon.
  • Lee J; Department of Emergency Medicine, Chungnam National University Hospital.
  • Ryu S; Department of Emergency Medicine, College of Medicine, Chungnam National University, Jung-gu, Daejeon.
  • Min JH; Department of Emergency Medicine, Chungnam National University Hospital.
  • Jeong WJ; Department of Emergency Medicine, College of Medicine, Chungnam National University, Jung-gu, Daejeon.
  • Cho YC; Department of Emergency Medicine, Chungnam National University Hospital.
  • Oh SK; Department of Emergency Medicine, Chungnam National University Hospital.
  • Ahn HJ; Department of Emergency Medicine, College of Medicine, Chungnam National University, Jung-gu, Daejeon.
  • Kang CS; Department of Emergency Medicine, Chungnam National University Sejong Hospital, Sejong.
  • Lee BK; Department of Emergency Medicine, Chungnam National University Hospital.
  • Lee DH; Department of Emergency Medicine, Chungnam National University Hospital.
  • Lee DH; Department of Emergency Medicine, College of Medicine, Chungnam National University, Jung-gu, Daejeon.
  • Yu GG; Department of Emergency Medicine, Chungnam National University Sejong Hospital, Sejong.
Medicine (Baltimore) ; 100(24): e26260, 2021 Jun 18.
Article en En | MEDLINE | ID: mdl-34128855
ABSTRACT: This study aimed to evaluate times for measuring serum lactate dehydrogenase levels (SLLs) to predict neurological prognosis among out-of-hospital cardiac arrest (OHCA) survivors.This retrospective study examined patients who experienced OHCA treated with targeted temperature management (TTM). The SLLs were evaluated at the return of spontaneous circulation (ROSC) and at 24, 48, and 72 hours later. Neurological outcomes after 3 months were evaluated for relationships with the SLL measurement times.A total of 95 comatose patients with OHCA were treated using TTM. Seventy three patients were considered eligible, including 31 patients (42%) who experienced good neurological outcomes. There were significant differences between the good and poor outcome groups at most time points (P < .001), except for ROSC (P = .06). The ROSC measurement had a lower area under the receiver operating characteristic curve (AUC: 0.631, 95% confidence interval [CI]: 0.502-0.761) than at 48 hours (AUC: 0.830, 95% CI: 0.736-0.924), at 24 hours (AUC: 0.786, 95% CI: 0.681-0.892), and at 72 hours (AUC: 0.821, 95% CI: 0.724-0.919).A higher SLL seemingly predicted poor neurological outcomes, with good prognostic values at 48 hours and 72 hours. Prospective studies should be conducted to confirm these results.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Tiempo / Coma / Paro Cardíaco Extrahospitalario / Hipotermia Inducida / L-Lactato Deshidrogenasa Tipo de estudio: Etiology_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Tiempo / Coma / Paro Cardíaco Extrahospitalario / Hipotermia Inducida / L-Lactato Deshidrogenasa Tipo de estudio: Etiology_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos