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Impact of age and gender on lymphocyte subset counts in patients with COVID-19.
Löhr, Phillip; Schiele, Stefan; Arndt, Tim Tobias; Grützner, Stefanie; Claus, Rainer; Römmele, Christoph; Müller, Gernot; Schmid, Christoph; Dennehy, Kevin M; Rank, Andreas.
Afiliación
  • Löhr P; Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany.
  • Schiele S; Institute of Mathematics, Faculty of Mathematics and Natural Sciences, University of Augsburg, Augsburg, Germany.
  • Arndt TT; Institute of Mathematics, Faculty of Mathematics and Natural Sciences, University of Augsburg, Augsburg, Germany.
  • Grützner S; Institute for Transfusion Medicine and Haemostasis, Medical Faculty, University of Augsburg, Augsburg, Germany.
  • Claus R; Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany.
  • Römmele C; Department of Gastroenterology and Infectious Diseases, Medical Faculty, University of Augsburg, Augsburg, Germany.
  • Müller G; Institute of Mathematics, Faculty of Mathematics and Natural Sciences, University of Augsburg, Augsburg, Germany.
  • Schmid C; Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany.
  • Dennehy KM; Institute for Laboratory Medicine and Microbiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
  • Rank A; Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Cytometry A ; 103(2): 127-135, 2023 02.
Article en En | MEDLINE | ID: mdl-34125495
In symptomatic patients with acute Coronavirus disease 2019 (COVID-19), lymphocytopenia is one of the most prominent laboratory findings. However, to date age and gender have not been considered in assessment of COVID-19-related cell count alterations. In this study, the impact of COVID-19 as well as age and gender on a large variety of lymphocyte subsets was analyzed in 33 COVID-19 patients and compared with cell counts in 50 healthy humans. We confirm that cell counts of total lymphocytes, B, NK, cytotoxic and helper T cells are reduced in patients with severe COVID-19, and this tendency was observed in patients with moderate COVID-19. Decreased cell counts were also found in all subsets of these cell types, except for CD4+ and CD8+ effector memory RA+ (EMRA) and terminal effector CD8+ cells. In multivariate analysis however, we show that in addition to COVID-19, there is an age-dependent reduction of total, central memory (CM), and early CD8+ cell subsets, as well as naïve, CM, and regulatory CD4+ cell subsets. Remarkably, reduced naïve CD8+ cell counts could be attributed to age alone, and not to COVID-19. By contrast, decreases in other subsets could be largely attributed to COVID-19, and only partly to age. In addition to COVID-19, male gender was a major factor influencing lower counts of CD3+ and CD4+ lymphocyte numbers. Our study confirms that cell counts of lymphocytes and their subsets are reduced in patients with COVID-19, but that age and gender must be considered when interpreting the altered cell counts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Aspecto: Determinantes_sociais_saude Límite: Humans / Male Idioma: En Revista: Cytometry A Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Aspecto: Determinantes_sociais_saude Límite: Humans / Male Idioma: En Revista: Cytometry A Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos