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Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity.
Kamdoum, Blaise Cedric; Simo, Ingrid; Wouamba, Steven Collins Njonte; Tchatat Tali, Brice Mariscal; Ngameni, Bathelemy; Fotso, Ghislain Wabo; Ambassa, Pantaléon; Fabrice, Fekam Boyom; Lenta, Bruno Ndjakou; Sewald, Norbert; Ngadjui, Bonaventure Tchaleu.
Afiliación
  • Kamdoum BC; Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
  • Simo I; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
  • Wouamba SCN; Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
  • Tchatat Tali BM; Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde, Cameroon.
  • Ngameni B; Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
  • Fotso GW; Department of pharmacy, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.
  • Ambassa P; Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
  • Fabrice FB; Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
  • Lenta BN; Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde, Cameroon.
  • Sewald N; Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
  • Ngadjui BT; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany.
Nat Prod Res ; 36(20): 5311-5318, 2022 Oct.
Article en En | MEDLINE | ID: mdl-34121522
An extensive phytochemical investigation of the EtOH/H2O (7:3) extracts of Sida rhombifolia L. and Sida acuta Burm. f., yielded a previously undescribed ceramide named rhombifoliamide (1) and a xylitol dimer (2), naturally isolated here for the first time, as well as the thirteen known compounds viz, oleanolic acid (3), ß-amyrin glucoside (4), ursolic acid (5), ß-sitosterol glucoside (6), tiliroside (7), 1,6-dihydroxyxanthone (8), a mixture of stigmasterol (9) and ß-sitosterol (10), cryptolepine (11), 20-Hydroxyecdysone (12), (E)-suberenol (13), thamnosmonin (14) and xanthyletin (15). Their structures were elucidated by the analyses of their spectroscopic and spectrometric data (1 D and 2 D NMR, and HRESI-MS) and by comparison with the previously reported data. The crude extracts, fractions, and some isolated compounds were tested against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains. All the tested samples demonstrated moderate and/or significant activities against 3D7 (IC50 values: 0.18-20.11 µg/mL) and Dd2 (IC50 values: 0.74-63.09 µg/mL).[Formula: see text].
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Oleanólico / Plantas Medicinales / Malvaceae / Antimaláricos País/Región como asunto: Africa Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Oleanólico / Plantas Medicinales / Malvaceae / Antimaláricos País/Región como asunto: Africa Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido