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Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li2 O·11.10ZrO2 ·69.32SiO2 glass-ceramic.
Possolli, Natália Morelli; da Silva, Daiara Floriano; Vieira, Jaqueline; Maurmann, Natasha; Pranke, Patricia; Demétrio, Ketner Bendo; Angioletto, Elidio; Montedo, Oscar Rubem Klegues; Arcaro, Sabrina.
Afiliación
  • Possolli NM; Engenharia Química, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
  • da Silva DF; Grupo de Biomateriais e Materiais Nanoestruturados, Programa de Pós-graduação em Ciência e Engenharia de Materiais, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
  • Vieira J; Grupo de Biomateriais e Materiais Nanoestruturados, Programa de Pós-graduação em Ciência e Engenharia de Materiais, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
  • Maurmann N; Programa de Pós-Graduação em Engenharia de Minas, Metalúrgica e de Materiais, Laboratório de Materiais Cerâmicos, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Pranke P; Laboratório de Hematologia e Células-tronco, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Demétrio KB; Laboratório de Hematologia e Células-tronco, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Angioletto E; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Montedo ORK; Laboratório de Hematologia e Células-tronco, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Arcaro S; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J Biomed Mater Res B Appl Biomater ; 110(1): 67-78, 2022 01.
Article en En | MEDLINE | ID: mdl-34121326
Glass and bioactive glass-ceramic can be used in several applications. In bone growth where good bone/biomaterial adhesion was required, bioactive coatings for implants can improve bone formation. The glass and glass-ceramics of the LZS (Li2 O-ZrO2 -SiO2 ) system are very interesting because of their mechanical, electrical, and thermal properties. Very recently, their biological response in contact with human osteoblast has been evaluated. However, despite several initiatives, there are still no studies that systematically assess this system's bioactivity, dissolution, and cytotoxicity in vitro. This work aims to investigate the dissolution, bioactivity behavior, and cytotoxicity of LZS glass-ceramic. LZS glass-ceramics were produced from SiO2 , Li2 CO3, and ZrSiO4 by melting followed by quenching. The obtained glass frits were milled and uniaxially pressed and heat-treated at 800 and 900°C and submitted to physical-chemical, structural and mechanical characterization. Their dissolution behavior was studied in Tris-HCl, while bioactivity was performed in simulated solution body fluid (SBF). The cytotoxicity test was performed using glass-ceramic in direct contact with mesenchymal stem/stromal cells (SC) isolated from human exfoliated deciduous teeth. Structural and microstructural analyzes confirmed bioactivity. The results show that it was possible to produce bioactive glass-ceramic from LZS, proven by the formation of new calcium phosphate structures such as hydroxyapatite on the surface of the samples after exposure to SBF. The SC viability test performed indicated that the materials were not cytotoxic at 0.25, 0.5, and 1.0 mg/ml. The glass-ceramic system under study is very promising for a medicinal application that requires bioactivity and/or biocompatibility for bone regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cerámica / Dióxido de Silicio Límite: Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cerámica / Dióxido de Silicio Límite: Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos