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Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident.
Cunningham, Kelly; Hinton, Thomas G; Luxton, Jared J; Bordman, Aryn; Okuda, Kei; Taylor, Lynn E; Hayes, Josh; Gerke, Hannah C; Chinn, Sarah M; Anderson, Donovan; Laudenslager, Mark L; Takase, Tsugiko; Nemoto, Yui; Ishiniwa, Hiroko; Beasley, James C; Bailey, Susan M.
Afiliación
  • Cunningham K; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1618, USA.
  • Hinton TG; Centre for Environmental Radioactivity, Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences (NMBU), P.O. Box 5003, N-1433 Ås, Norway; Institute of Environmental Radioactivity, 1 Kanayagawa, Fukushima City, Fukushima 960-1296, Japan. Electronic add
  • Luxton JJ; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1618, USA.
  • Bordman A; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1618, USA.
  • Okuda K; Faculty of Human Environmental Studies, Hiroshima Shudo University, Hiroshima 731-3195, Japan.
  • Taylor LE; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1618, USA.
  • Hayes J; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1618, USA.
  • Gerke HC; Savannah River Ecology Laboratory, Warnell School of Forestry and Natural Resources, University of Georgia, Aiken, SC 29808, USA.
  • Chinn SM; Savannah River Ecology Laboratory, Warnell School of Forestry and Natural Resources, University of Georgia, Aiken, SC 29808, USA.
  • Anderson D; Symbiotic Systems Science and Technology, Fukushima University, Fukushima, Fukushima City, Kanayagawa 960-1248, Japan.
  • Laudenslager ML; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Takase T; Institute of Environmental Radioactivity, 1 Kanayagawa, Fukushima City, Fukushima 960-1296, Japan.
  • Nemoto Y; Fukushima Prefectural Centre for Environmental Creation, 2-10 Fukasaku, Miharu, Fukushima 963-7799, Japan.
  • Ishiniwa H; Institute of Environmental Radioactivity, 1 Kanayagawa, Fukushima City, Fukushima 960-1296, Japan.
  • Beasley JC; Savannah River Ecology Laboratory, Warnell School of Forestry and Natural Resources, University of Georgia, Aiken, SC 29808, USA.
  • Bailey SM; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1618, USA.
Environ Int ; 155: 106675, 2021 10.
Article en En | MEDLINE | ID: mdl-34120002
The health effects associated with chronic low-dose, low-dose rate (LD-LDR) exposures to environmental radiation are uncertain. All dose-effect studies conducted outside controlled laboratory conditions are challenged by inherent complexities of ecological systems and difficulties quantifying dose to free-ranging organisms in natural environments. Consequently, the effects of chronic LD-LDR radiation exposures on wildlife health remain poorly understood and much debated. Here, samples from wild boar (Sus scrofa leucomystax) and rat snakes (Elaphe spp.) were collected between 2016 and 2018 across a gradient of radiation exposures in Fukushima, Japan. In vivo biomarkers of DNA damage and stress were evaluated as a function of multiple measurements of radiation dose. Specifically, we assessed frequencies of dicentric chromosomes (Telomere-Centromere Fluorescence in situ Hybridization: TC-FISH), telomere length (Telo-FISH, qPCR), and cortisol hormone levels (Enzyme Immunoassay: EIA) in wild boar, and telomere length (qPCR) in snakes. These biological parameters were then correlated to robust calculations of radiation dose rate at the time of capture and plausible upper bound lifetime dose, both of which incorporated internal and external dose. No significant relationships were observed between dicentric chromosome frequencies or telomere length and dose rate at capture or lifetime dose (p value range: 0.20-0.97). Radiation exposure significantly associated only with cortisol, where lower concentrations were associated with higher dose rates (r2 = 0.58; p < 0.0001), a relationship that was likely due to other (unmeasured) factors. Our results suggest that wild boar and snakes chronically exposed to LD-LDR radiation sufficient to prohibit human occupancy were not experiencing significant adverse health effects as assessed by biomarkers of DNA damage and stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monitoreo de Radiación / Accidente Nuclear de Fukushima Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Environ Int Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monitoreo de Radiación / Accidente Nuclear de Fukushima Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Environ Int Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos