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Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults.
Patel, Kershaw V; Simek, Shawn; Ayers, Colby; Neeland, Ian J; deFilippi, Christopher; Seliger, Stephen L; Lonergan, Katy; Minniefield, Nicole; Mentz, Robert J; Correa, Adolfo; Yimer, Wondwosen K; Hall, Michael E; Rodriguez, Carlos J; de Lemos, James A; Berry, Jarett D; Pandey, Ambarish.
Afiliación
  • Patel KV; Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.
  • Simek S; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Ayers C; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Neeland IJ; Division of Cardiology, Department of Medicine, University Hospitals Harrington Heart and Vascular Institute and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • deFilippi C; Inova Heart and Vascular Institute, Falls Church, Virginia, USA.
  • Seliger SL; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Lonergan K; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Minniefield N; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Mentz RJ; Division of Cardiology, Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Yimer WK; Department of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Rodriguez CJ; Division of Cardiology, Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
  • de Lemos JA; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Berry JD; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Pandey A; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: ambarish.pandey@utsouthwestern.edu.
JACC Heart Fail ; 9(7): 484-493, 2021 07.
Article en En | MEDLINE | ID: mdl-34119468
OBJECTIVES: This study sought to evaluate the independent associations and interactions between high-sensitivity cardiac troponin I (hs-cTnI) and physical activity (PA) with risk of heart failure (HF) subtypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF). BACKGROUND: Black adults are at high risk for developing HF. Physical inactivity and subclinical myocardial injury, as assessed by hs-cTnI concentration, are independent risk factors for HF. METHODS: Black adults from the Jackson Heart Study without prevalent HF who had hs-cTnI concentration and self-reported PA assessed at baseline were included. Adjusted Cox models were used to evaluate the independent and joint associations and interaction between hs-cTnI concentrations and PA with risk of HFpEF and HFrEF. RESULTS: Among 3,959 participants, 25.1% had subclinical myocardial injury (hs-cTnI ≥4 and ≥6 ng/l in women and men, respectively), and 48.2% were inactive (moderate-to-vigorous PA = 0 min/week). Over 12.0 years of follow-up, 163 and 150 participants had an incident HFpEF and HFrEF event, respectively. In adjusted analysis, higher hs-cTnI concentration (per 1-U log increase) was associated with higher risk of HFpEF (hazard ratio [HR]: 1.47; 95% confidence interval [CI]: 1.25 to 1.72]) and HFrEF (HR: 1.57; 95% CI: 1.35 to 1.83]). In contrast, higher PA (per 1-U log increase) was associated with a lower risk of HFpEF (HR: 0.93; 95% CI: 0.88 to 0.99]) but not HFrEF. There was a significant interaction between hs-cTnI and PA for risk of HFpEF (p interaction = 0.04) such that inactive participants with subclinical myocardial injury were at higher risk of HFpEF but active participants were not. CONCLUSIONS: Among Black adults with subclinical myocardial injury, higher levels of PA were associated with attenuated risk of HFpEF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Ventricular Izquierda / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: JACC Heart Fail Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Ventricular Izquierda / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: JACC Heart Fail Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos