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Risk of radiation necrosis after stereotactic radiosurgery for melanoma brain metastasis by anatomical location.
Choi, Siujoon; Hong, Angela; Wang, Tim; Lo, Seringe; Chen, Bi; Silva, Ines; Kapoor, Rony; Hsiao, Edward; Fogarty, Gerald B; Carlino, Matteo S; Menzies, Alexander M; Long, Georgina V; Shivalingam, Brindha S.
Afiliación
  • Choi S; Royal Prince Alfred Hospital, Camperdown, NSW, Australia. siujoon@gmail.com.
  • Hong A; Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
  • Wang T; Chris O'Brien Lifehouse, Camperdown, NSW, Australia.
  • Lo S; Melanoma Institute Australia, North Sydney, NSW, Australia.
  • Chen B; Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia.
  • Silva I; Melanoma Institute Australia, North Sydney, NSW, Australia.
  • Kapoor R; Crown Princess Mary Cancer Centre, Westmead, NSW, Australia.
  • Hsiao E; Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia.
  • Fogarty GB; Melanoma Institute Australia, North Sydney, NSW, Australia.
  • Carlino MS; Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia.
  • Menzies AM; Melanoma Institute Australia, North Sydney, NSW, Australia.
  • Long GV; Melanoma Institute Australia, North Sydney, NSW, Australia.
  • Shivalingam BS; Melanoma Institute Australia, North Sydney, NSW, Australia.
Strahlenther Onkol ; 197(12): 1104-1112, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34114045
PURPOSE: In this retrospective study, we have explored the anatomical factors that lead to the development of radiation necrosis (RN) in the setting of stereotactic radiosurgery (SRS) for melanoma brain metastases (MBM). METHODS: Between 2014 and 2018, 137 patients underwent SRS for 311 MBM. Lesions were assessed according to anatomical zones: zone 1-peripheral grey-white matter junction and cortical mantle, zone 2-deep white matter, including tumours located at base of sulci, zone 3-tumours adjacent to ependymal lining or in deep locations such as brainstem, basal ganglia and thalamus. Other anatomical factors including lobes, medial-peripheral, supra or infratentorial locations were also recorded. RESULTS: In all, 12.4% (n = 17) of patients and 6.1% (n = 20) of lesions developed RN, actuarial incidence of RN at 12 and 24 months was 10% and 14.2% respectively. Zone 2 lesions recorded the highest rate of development of RN (n = 7/19; 36%), zone 3 (N = 4/24; 16%) and zone 1 (n = 9/268; 3%). Five of 17 patients developed symptomatic RN and 7/17 patients underwent surgery for RN. CONCLUSION: This study raises awareness of the increased likelihood of deep lesions particularly in white matter structures to develop RN after SRS. Further studies including larger cohorts would be useful in identifying statistical differences in the rate of development of RN in different anatomical zones.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Radiocirugia / Melanoma Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Strahlenther Onkol Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Radiocirugia / Melanoma Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Strahlenther Onkol Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania