LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1&#945;/Hippo-YAP pathway.

Yang, Helin; Wang, Guangji; Liu, Jian; Lin, Mingxia; Chen, Jian; Fang, Yehan; Li, Yibo; Cai, Wentao; Zhan, Daolu

LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1α/Hippo-YAP pathway.

Yang, Helin; Wang, Guangji; Liu, Jian; Lin, Mingxia; Chen, Jian; Fang, Yehan; Li, Yibo; Cai, Wentao; Zhan, Daolu.

Afiliación

Yang H; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Wang G; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Liu J; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Lin M; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Chen J; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Fang Y; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Li Y; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Cai W; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China.
Zhan D; Departments of Spine Surgery and Sports Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Xiuying, Haikou, Hainan, 570311, PR China. Electronic address: 85796852@qq.com.

Biochem Biophys Res Commun ; 566: 16-23, 2021 08 20.

Article en En | MEDLINE | ID: mdl-34111667

Asunto(s)

Apoptosis; Núcleo Pulposo/citología; ARN Largo no Codificante/genética; Transducción de Señal; Proteínas Adaptadoras Transductoras de Señales/genética; Proteínas Adaptadoras Transductoras de Señales/metabolismo; Línea Celular; Proliferación Celular; Vía de Señalización Hippo; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; MicroARNs/genética; MicroARNs/metabolismo; Núcleo Pulposo/metabolismo; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; ARN Largo no Codificante/metabolismo; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; Proteínas Señalizadoras YAP

Palabras clave

HIF-1α; Hippo-YAP signaling Pathway; Nucleus pulposus cells; lncRNA JPX; microRNA-18a-5p

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Apoptosis / ARN Largo no Codificante / Núcleo Pulposo Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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