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A High-Resolution Ternary Model Demonstrates How PEGylated 2D Nanomaterial Stimulates Integrin αv ß8 on Cell Membrane.
Zhang, Xiao; Ding, Zhaowen; Ma, Guanghui; Wei, Wei.
Afiliación
  • Zhang X; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing, 100190, P. R. China.
  • Ding Z; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing, 100190, P. R. China.
  • Ma G; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing, 100190, P. R. China.
  • Wei W; School of Chemical Engineering, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, P. R. China.
Adv Sci (Weinh) ; 8(11): e2004506, 2021 06.
Article en En | MEDLINE | ID: mdl-34105291
Bio-nano interfaces are integral to all applications of nanomaterials in biomedicine. In addition to peptide-ligand-functionalized nanomaterials, passivation on 2D nanomaterials has emerged as a new regulatory factor for integrin activation. However, the mechanisms underlying such ligand-independent processes are poorly understood. Here, using graphene oxide passivated with polyethylene glycol (GO-PEG) as a test bed, a ternary simulation model is constructed that also includes a membrane and both subunits of integrin αv ß8 to characterize GO-PEG-mediated integrin activation on the cell membrane in a ligand-independent manner. Combined with the experimental findings, production simulations of the ternary model show a three-phase mechanotransduction process in the vertical interaction mode. Specifically, GO-PEG first induces lipid aggregation-mediated integrin proximity, followed by transmembrane domain rotation and separation, leading to the extension and activation of extracellular domains. Thus, this study presents a complete picture of the interaction between passivated 2D nanomaterials and cell membranes to mediate integrin activation, and provides insights into the potential de novo design and rational use of novel desirable nanomaterials at diverse bio-nano interfaces.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Integrina alfaV / Cadenas beta de Integrinas / Nanoestructuras / Grafito Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2021 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Integrina alfaV / Cadenas beta de Integrinas / Nanoestructuras / Grafito Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2021 Tipo del documento: Article Pais de publicación: Alemania