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Tributyltin and high-refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats.
Zanol, Jordana F; Niño, Oscar M S; da Costa, Charles S; Freitas-Lima, Leandro C; Miranda-Alves, Leandro; Graceli, Jones B.
Afiliación
  • Zanol JF; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: jozanol@hotmail.com.
  • Niño OMS; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil; Bachelor of Physical Education and Sports, Faculty of Human Sciences and Education, Universidad de los Llanos, Villavicencio-Meta, Colombia. Electro
  • da Costa CS; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: chsantoscosta@hotmail.com.
  • Freitas-Lima LC; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: lcf.lima@gmail.com.
  • Miranda-Alves L; Experimental Endocrinology Research, Development and Innovation Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Postgraduate Program in Endocrinology, School of Medicine, Federal University of Rio de Janeiro. Av. Carlos Chagas Filho, Ilha do Governador, Cidade
  • Graceli JB; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: jbgraceli@gmail.com.
Reprod Toxicol ; 103: 108-123, 2021 08.
Article en En | MEDLINE | ID: mdl-34102259
Exposure to the obesogen tributyltin (TBT) alone or high carbohydrate diet (HCD) alone leads to obesity and reproductive complications, such as premature ovary failure (POF) features. However, little is known about interactions between TBT and nutrition and their combined impact on reproduction. In this study, we assessed whether acute TBT and HCD exposure results in reproductive and metabolic irregularities. Female rats were treated with TBT (100 ng/kg/day) and fed with HCD for 15 days and metabolic and reproductive outcomes were assessed. TBT and HCD rats displayed metabolic impairments, such as increased adiposity, abnormal lipid profile and triglyceride and glucose (TYG) index, worsening adipocyte hypertrophy in HCD-TBT rats. These metabolic consequences were linked with reproductive disorders. Specifically, HCD-TBT rats displayed irregular estrous cyclicity, high follicle-stimulating hormone (FSH) levels, low anti-Müllerian hormone (AMH) levels, reduction in ovarian reserve, and corpora lutea (CL) number, with increases in atretic follicles, suggesting that HCD-TBT exposure exacerbated POF features. Further, strong negative correlations were observed between adipocyte hypertrophy and ovarian reserve, CL number and AMH levels. HCD-TBT exposure resulted in reproductive tract inflammation and fibrosis. Collectively, these data suggest that TBT plus HCD exposure leads to metabolic and reproductive abnormalities, exacerbating POF features in female rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Trialquiltina / Sustancias Peligrosas / Insuficiencia Ovárica Primaria Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Trialquiltina / Sustancias Peligrosas / Insuficiencia Ovárica Primaria Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos