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ANCA-associated vasculitis after COVID-19.
Izci Duran, Tugba; Turkmen, Ercan; Dilek, Melda; Sayarlioglu, Hayriye; Arik, Nurol.
Afiliación
  • Izci Duran T; Division of Rheumatology, Department of Internal Medicine, Ondokuz Mayis University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey. drtugbaizciduran@gmail.com.
  • Turkmen E; Division of Nephrology, Department of Internal Medicine, Ondokuz Mayis University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey.
  • Dilek M; Division of Nephrology, Department of Internal Medicine, Ondokuz Mayis University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey.
  • Sayarlioglu H; Division of Nephrology, Department of Internal Medicine, Ondokuz Mayis University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey.
  • Arik N; Division of Nephrology, Department of Internal Medicine, Ondokuz Mayis University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey.
Rheumatol Int ; 41(8): 1523-1529, 2021 08.
Article en En | MEDLINE | ID: mdl-34100115
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are systemic autoimmune diseases that may lead to renal failure due to the infiltration of mononuclear cells and the destruction of small- and medium-sized blood vessels. It has been shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger the presentation or exacerbation of autoimmune diseases. Crescentic glomerulonephritis (GN) has rarely been reported in patients with Coronavirus disease-2019 (COVID-19). We present rare two cases with AAV after a recent diagnosis of COVID-19. The first case was 26-year-old male patient, who was presented with acute kidney injury after COVID-19. Serum creatinine increased and active urine sediment was seen. Serological evaluation showed anti-myeloperoxidase antibody was at a level of 80.6 U/mL. Kidney biopsy showed necrotizing GN with cellular crescents. Methylprednisolone, cyclophosphamide and plasma exchange were administered. He was discharged with hemodialysis. Second case was a 36-year-old female who was hospitalized because of fever, cough and dyspnea. After she was diagnosed with COVID-19, she had total hearing loss, with cavitary lesions on bilateral lung parenchyma and an acute kidney injury. Serological evaluation showed an elevated anti-proteinase-3 with a level of 1:32. Kidney biopsy showed necrotizing GN with cellular crescents. Renal function improved after methylprednisolone and cyclophosphamide treatment. With a systematic review of the literature, we found four cases of new-onset AAV due to COVID-19. Herein, we discuss two cases and provide a literature review on cases of new-onset pauci-immune GN after COVID-19 infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatol Int Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatol Int Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania