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The relationship between serum thiol levels and thiol/disulfide homeostasis in women with tubal ectopic pregnancy.
Yildirim Köpük, Sule; Özer, Nida; Çekmez, Yasemin; Erel, Özcan; Kiran, Gürkan.
Afiliación
  • Yildirim Köpük S; Department of Obstetrics and Gynecology, Acibadem Maslak Hospital, Istanbul, Turkey. Electronic address: drsuleyildirimkpk@gmail.com.
  • Özer N; Private Clinic, Istanbul, Turkey.
  • Çekmez Y; Private Clinic, Istanbul, Turkey.
  • Erel Ö; Department of Biochemistry, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Kiran G; Department of Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul, Turkey.
J Gynecol Obstet Hum Reprod ; 50(9): 102175, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34089948
OBJECTIVE: The aim of this study was to investigate the thiol/disulfide homeostasis in tubal ectopic pregnancies in terms of early diagnosis of the disease. DESIGN: A prospective case-control study was carried out between June 2017-February 2018 in the Gynaecology Department of Umraniye Medical and Research Hospital. MATERIALS AND METHODS: A total of 42 women with ectopic pregnancy were compared with 44 healthy women who have intrauterine first trimester pregnancies. The thiol/disulfide homeostasis is evaluated with the spectrophotometric measurement method that was recently developed by Erel&Neselioglu. RESULTS: Disulfide/native thiol and disulfide/total thiol ratios were increased (p = 0.018 and p = 0.023 respectively), while native thiol/total thiol ratios and native thiol levels were decreased in tubal ectopic pregnancy group according to control group (p = 0.023). Between control and tubal ectopic pregnancy groups no differences were measured in disulfide levels (p = 0.350). The area under curve for native thiol and total thiol were 0.937 and 0.927, respectively. The optimum cut off value for native thiol was 379.95 µmol/l with a sensitivity of 90% and specificity of 81%. The optimum cut off value for total thiol was 432.5 µmol/l had 92% sensitivity and 79% specificity. LIMITATIONS: In the study, whether intrauterine pregnancies resulted in miscarriage or delivery can be examined. CONCLUSION: Increased disulfide/native thiol levels, disulfide/total-thiol ratio and decreased native/total thiol ratio were found to be significantly associated with the presence of tubal ectopic pregnancy which can be useful for the early diagnosis of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embarazo Ectópico / Proteína Disulfuro Reductasa (Glutatión) / Compuestos de Sulfhidrilo / Trompas Uterinas Tipo de estudio: Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: J Gynecol Obstet Hum Reprod Año: 2021 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embarazo Ectópico / Proteína Disulfuro Reductasa (Glutatión) / Compuestos de Sulfhidrilo / Trompas Uterinas Tipo de estudio: Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: J Gynecol Obstet Hum Reprod Año: 2021 Tipo del documento: Article Pais de publicación: Francia