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PID1 is associated to a respiratory endotype related to occupational exposures to irritants.
Andrianjafimasy, Miora; Orsi, Laurent; Margaritte-Jeannin, Patricia; Mohamdi, Hamida; Demenais, Florence; Le Moual, Nicole; Matran, Regis; Zerimech, Farid; Dumas, Orianne; Dizier, Marie-Hélène; Nadif, Rachel.
Afiliación
  • Andrianjafimasy M; Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe d'Epidémiologie Respiratoire Intégrative, F-94807, Villejuif, France.
  • Orsi L; Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe d'Epidémiologie Respiratoire Intégrative, F-94807, Villejuif, France.
  • Margaritte-Jeannin P; Université de Paris, UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, F-75006, Paris, France.
  • Mohamdi H; Université de Paris, UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, F-75006, Paris, France.
  • Demenais F; Université de Paris, UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, F-75006, Paris, France.
  • Le Moual N; Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe d'Epidémiologie Respiratoire Intégrative, F-94807, Villejuif, France.
  • Matran R; Univ. Lille, ULR 4483, IMPECS, F-59000, Lille, France; CHU Lille, F-59000, Lille, France; Institut Pasteur de Lille, F-59000, Lille, France.
  • Zerimech F; Univ. Lille, ULR 4483, IMPECS, F-59000, Lille, France; CHU Lille, F-59000, Lille, France; Institut Pasteur de Lille, F-59000, Lille, France.
  • Dumas O; Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe d'Epidémiologie Respiratoire Intégrative, F-94807, Villejuif, France.
  • Dizier MH; Université de Paris, UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, F-75006, Paris, France. Electronic address: marie-helene.dizier@inserm.fr.
  • Nadif R; Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe d'Epidémiologie Respiratoire Intégrative, F-94807, Villejuif, France.
Free Radic Biol Med ; 172: 503-507, 2021 08 20.
Article en En | MEDLINE | ID: mdl-34087431
BACKGROUND: Studying associations between genes and asthma endotypes and interactions with environment could help to identify new susceptibility genes. We used a previously identified asthma endotype characterized by adult-onset asthma, poor lung function, and high level of Fluorescent oxidation products, a marker of damages due to oxidative stress. This endotype was associated with high occupational exposure to irritants. We aimed to investigate the associations between genes related to oxidative stress and this endotype, and if the associations differed according to irritants exposure. METHODS: We conducted association analyses between the asthma endotype and genetic variants (4715 SNPs) located in 422 genes involved in the "response to oxidative stress" in adults from the Epidemiological study on the Genetic and Environment of Asthma. Analyses using logistic regression were conducted first in all participants, and then separately among high vs. non-exposed participants to assess whether association differs according to irritants exposure. RESULTS: An association was found between the SNP rs1419958 located in PID1 gene and the endotype (P = 2.2E-05), reaching significance level after correction for multiple testing. This association was even more significant in non-exposed participants (P = 1.06E-06) while there was no association in participants with high exposure to occupational irritants. CONCLUSION: This study showed a significant association between an asthma endotype and PID1, a promising candidate gene, the association being different according to the exposure to irritants. These results highlight the interest of studying asthma endotypes in association with genes from candidate pathways and their link with occupational irritants to decipher asthma etiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Exposición Profesional Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Exposición Profesional Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos