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The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair.
Wei, Yulong; Sun, Hao; Gui, Tao; Yao, Lutian; Zhong, Leilei; Yu, Wei; Heo, Su-Jin; Han, Lin; Dyment, Nathaniel A; Liu, Xiaowei Sherry; Zhang, Yejia; Koyama, Eiki; Long, Fanxin; Zgonis, Miltiadis H; Mauck, Robert L; Ahn, Jaimo; Qin, Ling.
Afiliación
  • Wei Y; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Sun H; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Gui T; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Yao L; Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Zhong L; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Yu W; Department of Bone and Joint Surgery, Institute of Orthopedic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou, China.
  • Heo SJ; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Han L; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Dyment NA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Liu XS; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang Y; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Koyama E; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States.
  • Long F; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, United States.
  • Zgonis MH; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Mauck RL; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Ahn J; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Qin L; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, United States.
Elife ; 102021 06 04.
Article en En | MEDLINE | ID: mdl-34085927
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the development of meniscus horns from 2 weeks of age. In adult mice, Gli1+ cells resided at the superficial layer of meniscus and expressed known mesenchymal progenitor markers. In culture, meniscal Gli1+ cells possessed high progenitor activities under the control of Hh signal. Meniscus injury at the anterior horn induced a quick expansion of Gli1-lineage cells. Normally, meniscal tissue healed slowly, leading to cartilage degeneration. Ablation of Gli1+ cells further hindered this repair process. Strikingly, intra-articular injection of Gli1+ meniscal cells or an Hh agonist right after injury accelerated the bridging of the interrupted ends and attenuated signs of osteoarthritis. Taken together, our work identified a novel progenitor population in meniscus and proposes a new treatment for repairing injured meniscus and preventing osteoarthritis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Meniscos Tibiales / Osteoartritis de la Rodilla / Trasplante de Células Madre Mesenquimatosas / Proteínas Hedgehog / Células Madre Mesenquimatosas / Lesiones de Menisco Tibial / Proteína con Dedos de Zinc GLI1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Meniscos Tibiales / Osteoartritis de la Rodilla / Trasplante de Células Madre Mesenquimatosas / Proteínas Hedgehog / Células Madre Mesenquimatosas / Lesiones de Menisco Tibial / Proteína con Dedos de Zinc GLI1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido