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Collicular circuits for flexible sensorimotor routing.
Duan, Chunyu A; Pagan, Marino; Piet, Alex T; Kopec, Charles D; Akrami, Athena; Riordan, Alexander J; Erlich, Jeffrey C; Brody, Carlos D.
Afiliación
  • Duan CA; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. c.duan@ucl.ac.uk.
  • Pagan M; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. c.duan@ucl.ac.uk.
  • Piet AT; Sainsbury Wellcome Centre, UCL, London, UK. c.duan@ucl.ac.uk.
  • Kopec CD; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
  • Akrami A; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
  • Riordan AJ; Allen Institute for Brain Science, Seattle, WA, USA.
  • Erlich JC; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
  • Brody CD; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Nat Neurosci ; 24(8): 1110-1120, 2021 08.
Article en En | MEDLINE | ID: mdl-34083787
Context-based sensorimotor routing is a hallmark of executive control. Pharmacological inactivations in rats have implicated the midbrain superior colliculus (SC) in this process. But what specific role is this, and what circuit mechanisms support it? Here we report a subset of rat SC neurons that instantiate a specific link between the representations of context and motor choice. Moreover, these neurons encode animals' choice far earlier than other neurons in the SC or in the frontal cortex, suggesting that their neural dynamics lead choice computation. Optogenetic inactivations revealed that SC activity during context encoding is necessary for choice behavior, even while that choice behavior is robust to inactivations during choice formation. Searches for SC circuit models matching our experimental results identified key circuit predictions while revealing some a priori expected features as unnecessary. Our results reveal circuit mechanisms within the SC that implement response inhibition and context-based vector inversion during executive control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta de Elección / Colículos Superiores / Vías Nerviosas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta de Elección / Colículos Superiores / Vías Nerviosas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos