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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.
Brioschi, Simone; Wang, Wei-Le; Peng, Vincent; Wang, Meng; Shchukina, Irina; Greenberg, Zev J; Bando, Jennifer K; Jaeger, Natalia; Czepielewski, Rafael S; Swain, Amanda; Mogilenko, Denis A; Beatty, Wandy L; Bayguinov, Peter; Fitzpatrick, James A J; Schuettpelz, Laura G; Fronick, Catrina C; Smirnov, Igor; Kipnis, Jonathan; Shapiro, Virginia S; Wu, Gregory F; Gilfillan, Susan; Cella, Marina; Artyomov, Maxim N; Kleinstein, Steven H; Colonna, Marco.
Afiliación
  • Brioschi S; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Wang WL; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Peng V; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Wang M; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.
  • Shchukina I; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Greenberg ZJ; Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Bando JK; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Jaeger N; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Czepielewski RS; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Swain A; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Mogilenko DA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Beatty WL; Department of Molecular Microbiology, Center for Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Bayguinov P; Washington University Center for Cellular Imaging, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Fitzpatrick JAJ; Washington University Center for Cellular Imaging, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Schuettpelz LG; Departments of Cell Biology and Physiology and Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Fronick CC; Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, MO 63130, USA.
  • Smirnov I; Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Kipnis J; McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Shapiro VS; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Wu GF; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Gilfillan S; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  • Cella M; Department of Neurology, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
  • Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Kleinstein SH; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
  • Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Science ; 373(6553)2021 07 23.
Article en En | MEDLINE | ID: mdl-34083450
The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging, bone marrow chimeras, and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvarial-meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells, which may help maintain immune privilege within the CNS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cráneo / Células de la Médula Ósea / Linfocitos B / Sistema Nervioso Central / Subgrupos de Linfocitos B / Linfopoyesis / Duramadre / Meninges Límite: Animals Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cráneo / Células de la Médula Ósea / Linfocitos B / Sistema Nervioso Central / Subgrupos de Linfocitos B / Linfopoyesis / Duramadre / Meninges Límite: Animals Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos