MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2).

Jinghua, Huang; Qinghua, Zhou; Chenchen, Chen; Lili, Chen; Xiao, Xu; Yunfei, Wang; Zhengzhe, An; Changxiu, Lin; Hui, Han

Jinghua, Huang; Qinghua, Zhou; Chenchen, Chen; Lili, Chen; Xiao, Xu; Yunfei, Wang; Zhengzhe, An; Changxiu, Lin; Hui, Han.

Afiliación

Jinghua H; Department of Radiation Oncology, Affiliated Hospital of Yanbian University, Yanbian, Jilin, China.
Qinghua Z; Department of Pain Control, Zoucheng People 'S Hospital, Shandong, China.
Chenchen C; Department of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.
Lili C; Department of Anesthesiology, Huaiyin People's Hospital, Huaiyin District, Jinan, Shandong, China.
Xiao X; Department of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.
Yunfei W; Department of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.
Zhengzhe A; Department of Radiation Oncology, Affiliated Hospital of Yanbian University, Yanbian, Jilin, China.
Changxiu L; Central Laboratory, Affiliated Hospital of Yanbian University, Yanbian, Jilin, China.
Hui H; Department of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.

Bioengineered ; 12(1): 2033-2044, 2021 12.

Article en En | MEDLINE | ID: mdl-34082648

RESUMEN

MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers' occurrence and progression. This study focuses on miR-92a-3p's functions and regulatory mechanism in breast cancer (BC). The current study proved miR-92a-3p expression was enhanced in BC tissues and cells, and its high expression was related to increased TNM stage and larger tumor size of BC patients. Functionally, transfection of miR-92a-3p mimics facilitated BC cell proliferation and metastasis, yet transfection of miR-92a-3p inhibitors functioned oppositely. In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells. This research indicated that miR-92a-3p facilitates BC cell proliferation and metastasis through repressing BTG2 expression.

Asunto(s)

Neoplasias de la Mama; Proteínas Inmediatas-Precoces/metabolismo; MicroARNs/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Mama/metabolismo; Mama/patología; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Línea Celular Tumoral; Proliferación Celular/genética; Femenino; Humanos; Proteínas Inmediatas-Precoces/genética; MicroARNs/genética; Persona de Mediana Edad; Metástasis de la Neoplasia/genética; Metástasis de la Neoplasia/patología; Proteínas Supresoras de Tumor/genética

Palabras clave

BTG2; Breast cancer; miR-92a-3p

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Inmediatas-Precoces / Proteínas Supresoras de Tumor / MicroARNs Límite: Female / Humans / Middle aged Idioma: En Revista: Bioengineered Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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