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Genome-Wide Linkage Study Meta-Analysis of Male Sexual Orientation.
Sanders, Alan R; Beecham, Gary W; Guo, Shengru; Badner, Judith A; Bocklandt, Sven; Mustanski, Brian S; Hamer, Dean H; Martin, Eden R.
Afiliación
  • Sanders AR; Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, 1001 University Place, Evanston, IL, 60201, USA. alan.sanders.md@gmail.com.
  • Beecham GW; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. alan.sanders.md@gmail.com.
  • Guo S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Badner JA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Bocklandt S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Mustanski BS; Department of Psychiatry, Rush University, Chicago, IL, USA.
  • Hamer DH; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Martin ER; Department of Medical Social Sciences, Northwestern University, Evanston, IL, USA.
Arch Sex Behav ; 50(8): 3371-3375, 2021 11.
Article en En | MEDLINE | ID: mdl-34080073
Male sexual orientation is a scientifically and socially important trait shown by family and twin studies to be influenced by environmental and complex genetic factors. Individual genome-wide linkage studies (GWLS) have been conducted, but not jointly analyzed. Two main datasets account for > 90% of the published GWLS concordant sibling pairs on the trait and are jointly analyzed here: MGSOSO (Molecular Genetic Study of Sexual Orientation; 409 concordant sibling pairs in 384 families, Sanders et al. (2015)) and Hamer (155 concordant sibling pairs in 145 families, Mustanski et al. (2005)). We conducted multipoint linkage analyses with Merlin on the datasets separately since they were genotyped differently, integrated genetic marker positions, and combined the resultant LOD (logarithm of the odds) scores at each 1 cM grid position. We continue to find the strongest linkage support at pericentromeric chromosome 8 and chromosome Xq28. We also incorporated the remaining published GWLS dataset (on 55 families) by using meta-analytic approaches on published summary statistics. The meta-analysis has maximized the positional information from GWLS of currently available family resources and can help prioritize findings from genome-wide association studies (GWAS) and other approaches. Although increasing evidence highlights genetic contributions to male sexual orientation, our current understanding of contributory loci is still limited, consistent with the complexity of the trait. Further increasing genetic knowledge about male sexual orientation, especially via large GWAS, should help advance our understanding of the biology of this important trait.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Estudio de Asociación del Genoma Completo Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Arch Sex Behav Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Estudio de Asociación del Genoma Completo Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Arch Sex Behav Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos