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Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis.
Ide, Kazuki; Matsuoka, Norihiro; Fujita, Misao.
Afiliación
  • Ide K; Division of Scientific Information and Public Policy, Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka 565-0871, Japan.
  • Matsuoka N; Uehiro Research Division for iPS Cell Ethics, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
  • Fujita M; The Institute of Natural Sciences, College of Humanities and Sciences, Nihon University, Tokyo 156-8550, Japan.
Medicina (Kaunas) ; 57(6)2021 May 27.
Article en En | MEDLINE | ID: mdl-34071749
Background and Objectives: Brain organoids are self-assembled, three-dimensional (3D) aggregates generated from pluripotent stem cells. These models are useful for experimental studies on human brain development and function and are therefore increasingly used for research worldwide. As their increasing use raises several ethical questions, we aimed to assess the current state of the press on brain organoid research using a cross-sectional database to understand the extent of discussion of this subject in the public. Materials and Methods: We conducted a descriptive analysis of news reports obtained from the Nexis Uni database, searched in April 2020. After extracting the news reports, the number of published reports in each year and the included terms were analyzed. Results: Up to April 2020, 332 news reports had been published, with over half of them published in the United States and the United Kingdom, with the numbers gradually increasing every year. In total, 113 (34.0%) news reports included ethics-related keywords, and the ratio of studies before and after the study-period midpoint was significantly increased (21.0% (2013-2016) vs. 38.2% (2017-2020); p = 0.0066, Chi-square test with Yates' continuity correction). Conclusions: Although news reports on the ethical aspects of brain organoid research have been increasing gradually, there was a bias in the region of publication. Additional studies focusing on the ethical aspects of brain organoid research should strive to assess the public perception on the subject in different parts of the world.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Organoides Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Ethics Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Organoides Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Ethics Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza