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Exposure of Culicoides sonorensis to Enzootic Strains of Bluetongue Virus Demonstrates Temperature- and Virus-Specific Effects on Virogenesis.
Kopanke, Jennifer; Lee, Justin; Stenglein, Mark; Carpenter, Molly; Cohnstaedt, Lee W; Wilson, William C; Mayo, Christie.
Afiliación
  • Kopanke J; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
  • Lee J; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
  • Stenglein M; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
  • Carpenter M; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
  • Cohnstaedt LW; Arthropod-Borne Animal Diseases Research Unit, United States Department of Agriculture-Agricultural Research Service, Manhattan, KS 66502, USA.
  • Wilson WC; National Bio and Agro-Defense Facility (NBAF), United States Department of Agriculture-Agricultural Research Service, 1880 Kimball Ave, Suite 300 CGAHR, Manhattan, KS 66502, USA.
  • Mayo C; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Viruses ; 13(6)2021 05 28.
Article en En | MEDLINE | ID: mdl-34071483
Bluetongue virus (BTV) is a segmented RNA virus transmitted by Culicoides midges. Climatic factors, animal movement, vector species, and viral mutation and reassortment may all play a role in the occurrence of BTV outbreaks among susceptible ruminants. We used two enzootic strains of BTV (BTV-2 and BTV-10) to explore the potential for Culicoides sonorensis, a key North American vector, to be infected with these viruses, and identify the impact of temperature variations on virogenesis during infection. While BTV-10 replicated readily in C. sonorensis following an infectious blood meal, BTV-2 was less likely to result in productive infection at biologically relevant exposure levels. Moreover, when C. sonorensis were co-exposed to both viruses, we did not detect reassortment between the two viruses, despite previous in vitro findings indicating that BTV-2 and BTV-10 are able to reassort successfully. These results highlight that numerous factors, including vector species and exposure dose, may impact the in vivo replication of varying BTV strains, and underscore the complexities of BTV ecology in North America.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temperatura / Lengua Azul / Virus de la Lengua Azul / Dípteros Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temperatura / Lengua Azul / Virus de la Lengua Azul / Dípteros Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza