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Evaluation of the Wound Healing Potential of Some Natural Polymers on Three Experimental Models.
Andritoiu, Calin Vasile; Andriescu, Corina Elena; Danu, Maricel; Lungu, Cristina; Ivanescu, Bianca; Havarneanu, Cornel; Popa, Marcel.
Afiliación
  • Andritoiu CV; Apitherapy Medical Center, Balanesti, 217036 Gorj, Romania.
  • Andriescu CE; Nutrition and Dietetics Specialization, Faculty of Pharmacy, Vasile Goldis Western University of Arad, 310025 Arad, Romania.
  • Danu M; Department of Pathology, Sf. Spiridon Emergency County Hospital, 700111 Iasi, Romania.
  • Lungu C; Petru Poni Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
  • Ivanescu B; Department of Natural and Synthetic Polymers, Cristofor Simionescu Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania.
  • Havarneanu C; Department of Pharmaceutical Botany, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
  • Popa M; Department of Pharmaceutical Botany, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Pharmaceuticals (Basel) ; 14(5)2021 May 14.
Article en En | MEDLINE | ID: mdl-34069274
The aim of this paper was the preparation and investigation of the wound healing properties of four topical formulations based on natural polymers such as collagen, chitosan, lyophilized egg white, and a mixture of them. The therapeutic assessment of these four ointments was carried out in vivo on the incision, excision, and thermal burn wounds induced on Wistar rats. The treatment was applied topically on wounds once a day, for 21 days. The experimental results were analyzed from a clinical and histopathological point of view. The rheological characterization of the topical formulations was also performed in order to verify their spreadability and structural stability. All ointments had a positive effect on wound contraction and re-epithelization processes, but the one based on total polymers had a significant healing potential on the designed cutaneous lesions due to its synergistic effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza