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Sodium Butyrate More Effectively Mitigates the Negative Effects of High-Concentrate Diet in Dairy Cows than Sodium ß-Hydroxybutyrate via Reducing Free Bacterial Cell Wall Components in Rumen Fluid and Plasma.
Wu, Yongjiang; Sun, Yawang; Zhang, Ruiming; He, Tianle; Huang, Guohao; Tian, Ke; Liu, Junhui; Chen, Juncai; Dong, Guozhong.
Afiliación
  • Wu Y; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • Sun Y; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • Zhang R; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • He T; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • Huang G; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • Tian K; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • Liu J; United Graduate School of Agricultural Science, Gifu University, Gifu 501-1193, Japan.
  • Chen J; College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
  • Dong G; Centre for Research in Agricultural Genomics (CRAG), University Autonomous of Barcelona, 08193 Barcelona, Spain.
Toxins (Basel) ; 13(5)2021 05 14.
Article en En | MEDLINE | ID: mdl-34069117
The present study was aimed at investigating the effects of sodium butyrate and sodium ß-hydroxybutyrate on lactation and health of dairy cows fed a high-concentrate (HC) diet. Eighty mid-lactation dairy cows with an average milk yield of 33.75 ± 5.22 kg/d were randomly allocated to four groups (n = 20 per group) and were fed either a low-concentrate (LC) diet, a HC diet, the HC diet with 1% sodium butyrate (HCSB), or the HC diet with 1% sodium ß-hydroxybutyrate (HCHB). The feeding trial lasted for 7 weeks, with a 2-week adaptation period and a 5-week measurement period, and the trial started from 96 ± 13 d in milk. Sodium butyrate supplementation delayed the decline in milk production and improved milk synthesis efficiency and milk fat content. Additionally, it decreased the proinflammatory cytokines and acute phase proteins (APPs) in plasma, the leucocytes in blood, the somatic cell count (SCC) in milk, and the gene expression of pattern recognition receptors (PRRs) and proinflammatory cytokines in the mammary gland, due to decreasing the contents of bacterial cell wall components (lipopolysaccharide, LPS; peptidoglycan, PGN; and lipoteichoic acid, LTA) in the rumen and plasma, compared with the HC diet. Sodium ß-hydroxybutyrate supplementation also improved milk yield, milk synthesis efficiency and milk fat content and partially reduced the adverse effects caused by the HC diet, but it had no effect on decreasing bacterial cell wall components in the rumen and plasma, compared with the HC diet. Collectively, both sodium butyrate and sodium ß-hydroxybutyrate mitigated the negative effects of HC diet on lactation and health of dairy cows, with sodium butyrate being more effective than sodium ß-hydroxybutyrate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Ácido Butírico / Ácido 3-Hidroxibutírico / Alimentación Animal Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Ácido Butírico / Ácido 3-Hidroxibutírico / Alimentación Animal Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza