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The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures.
Rigos, Ioannis; Athanasiou, Vasileios; Vlahos, Nikolaos; Papantoniou, Nikolaos; Profer, Dimitrios; Siristatidis, Charalampos.
Afiliación
  • Rigos I; Assisted Reproduction Unit, IVF Athens Center, Leof. Kifisias 5, 15123 Athens, Greece.
  • Athanasiou V; Assisted Reproduction Unit, IVF Athens Center, Leof. Kifisias 5, 15123 Athens, Greece.
  • Vlahos N; Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, "Aretaieion Hospital", Medical School, National and Kapodistrian University of Athens, Vas. Sofias 76, 11528 Athens, Greece.
  • Papantoniou N; Third Department of Obstetrics and Gynecology, "Attikon Hospital", Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12642 Athens, Greece.
  • Profer D; Independent Researcher, Pontou 9-11, 62125 Serres, Greece.
  • Siristatidis C; Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, "Aretaieion Hospital", Medical School, National and Kapodistrian University of Athens, Vas. Sofias 76, 11528 Athens, Greece.
J Clin Med ; 10(10)2021 May 17.
Article en En | MEDLINE | ID: mdl-34067637
(1) Background: Recurrent implantation failure (RIF) after IVF remains a challenging topic for fertility specialists and a frustrating reality for patients with infertility. Various approaches have been investigated and applied towards the improvement of clinical outcomes. Through a nonrandomized clinical trial, we evaluated the effect of the combination of hysteroscopic endometrial injury and the freeze-all technique on pregnancy parameters in a cohort of RIF patients; (2) Methods: The study group comprised of 30 patients with RIF that underwent a hysteroscopic endometrial injury prior to a frozen embryo transfer cycle; another 30 patients with RIF, comprising the control group, underwent a standard frozen cycle with no adjuvant treatment before. Live birth comprised the primary outcome. Logistic and Poisson regression analyses were implemented to reveal potential independent predictors for all outcomes. (3) Results: Live birth rates were similar between groups (8/30 vs. 3/30, p = 0.0876). Biochemical and clinical pregnancy and miscarriages were also independent of the procedure (p = 0.7812, p = 0.3436 and p = 0.1213, respectively). The only confounding factor that contributed to biochemical pregnancy was the number of retrieved oocytes (0.1618 ± 0.0819, p = 0.0481); (4) Conclusions: The addition of endometrial injury to the freeze-all strategy in infertile women with RIF does not significantly improve pregnancy rates, including live birth. A properly conducted RCT with adequate sample size could give a robust answer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza