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A Stepwise Approach Using Metastatic Lymph Node Ratio-Combined Thyroglobulin for Customization of [18F]FDG-PET/CT Indication to Detect Persistent Disease in Patients with Papillary Thyroid Cancer.
Piao, Hong Hua; Jeon, Subin; Yoo, Su Woong; Ryu, Young Jae; Kim, Dong-Yeon; Pyo, Ayoung; Bom, Hee-Seung; Min, Jung-Joon; Kwon, Seong Young.
Afiliación
  • Piao HH; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.
  • Jeon S; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.
  • Yoo SW; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.
  • Ryu YJ; Department of Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun-gun 58128, Korea.
  • Kim DY; College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju 52828, Korea.
  • Pyo A; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.
  • Bom HS; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.
  • Min JJ; Department of Nuclear Medicine, Chonnam National University Medical School, Hwasun-gun 58128, Korea.
  • Kwon SY; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.
Diagnostics (Basel) ; 11(5)2021 May 06.
Article en En | MEDLINE | ID: mdl-34066574
We investigated whether an indication for [18F]FDG-PET/CT to detect FDG-avid persistent disease (PD) could be identified precisely using the extent of metastatic lymph nodes (MLNs) and serum thyroglobulin (Tg) in papillary thyroid cancer (PTC) patients. This retrospective study included 429 PTC patients who underwent surgery and radioactive iodine (RAI) therapy. [18F]FDG-PET/CT and serum Tg were evaluated just before RAI therapy. The MLN ratio (LNR) was defined as the ratio of the number of MLNs to the number of removed LNs. To derive the LNR-combined criteria, different Tg cut-off values for identifying the PET/CT-indicated group for PD detection were applied individually to subgroups initially classified based on LNR cut-off values. The cut-off values for serum Tg, the number of MLNs, and LNR for a PET/CT indication were 6.0 ng/mL, 5, and 0.51, respectively. Compared to a single parameter (serum Tg, total number of MLNs, and LNR), the LNR-combined criteria showed significantly superior diagnostic performance in detecting FDG-avid PD (p < 0.001). The diagnostic performance of PET/CT in detecting FDG-avid PD was significantly improved when the PET/CT-indicated group was identified through the LNR-combined criteria in a stepwise manner; this can contribute to a customized PET/CT indication in PTC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Año: 2021 Tipo del documento: Article Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Año: 2021 Tipo del documento: Article Pais de publicación: Suiza