Your browser doesn't support javascript.
loading
Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy.
Wenzel, Mike; Preisser, Felix; Wittler, Clarissa; Hoeh, Benedikt; Wild, Peter J; Tschäbunin, Alexandra; Bodelle, Boris; Würnschimmel, Christoph; Tilki, Derya; Graefen, Markus; Becker, Andreas; Karakiewicz, Pierre I; Chun, Felix K H; Kluth, Luis A; Köllermann, Jens; Mandel, Philipp.
Afiliación
  • Wenzel M; Department of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, Germany.
  • Preisser F; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC H2X 3E4, Canada.
  • Wittler C; Department of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, Germany.
  • Hoeh B; Department of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, Germany.
  • Wild PJ; Department of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, Germany.
  • Tschäbunin A; Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590 Frankfurt, Germany.
  • Bodelle B; Frankfurt Institute for Advanced Studies (FIAS), 60590 Frankfurt, Germany.
  • Würnschimmel C; Wildlab, University Hospital Frankfurt MVZ GmbH, 60590 Frankfurt, Germany.
  • Tilki D; Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590 Frankfurt, Germany.
  • Graefen M; Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, 60590 Frankfurt, Germany.
  • Becker A; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC H2X 3E4, Canada.
  • Karakiewicz PI; Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • Chun FKH; Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • Kluth LA; Department of Urology, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • Köllermann J; Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • Mandel P; Department of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, Germany.
Diagnostics (Basel) ; 11(5)2021 May 15.
Article en En | MEDLINE | ID: mdl-34063557
BACKGROUND: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear. METHODS: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB GS, as well as for the combined effect of SB + TB. RESULTS: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman's correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both p < 0.001), but a higher downgrading rate, relative to TB (p < 0.01). CONCLUSIONS: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza