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Poly(ethylene-imine)-Functionalized Magnetite Nanoparticles Derivatized with Folic Acid: Heating and Targeting Properties.
Ortega-Muñoz, Mariano; Plesselova, Simona; Delgado, Angel V; Santoyo-Gonzalez, Francisco; Salto-Gonzalez, Rafael; Giron-Gonzalez, Maria Dolores; Iglesias, Guillermo R; López-Jaramillo, Francisco Javier.
Afiliación
  • Ortega-Muñoz M; Department of Organic Chemistry, Institute of Biotechnology, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
  • Plesselova S; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
  • Delgado AV; Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
  • Santoyo-Gonzalez F; Department of Organic Chemistry, Institute of Biotechnology, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
  • Salto-Gonzalez R; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
  • Giron-Gonzalez MD; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
  • Iglesias GR; Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
  • López-Jaramillo FJ; Department of Organic Chemistry, Institute of Biotechnology, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
Polymers (Basel) ; 13(10)2021 May 15.
Article en En | MEDLINE | ID: mdl-34063481
Magnetite nanoparticles (MNPs) coated by branched poly (ethylene-imine) (PEI) were synthesized in a one-pot. Three molecular weights of PEI were tested, namely, 1.8 kDa (sample MNP-1), 10 kDa (sample MNP-2), and 25 kDa (sample MNP-3). The MNP-1 particles were further functionalized with folic acid (FA) (sample MNP-4). The four types of particles were found to behave magnetically as superparamagnetic, with MNP-1 showing the highest magnetization saturation. The particles were evaluated as possible hyperthermia agents by subjecting them to magnetic fields of 12 kA/m strength and frequencies ranging between 115 and 175 kHz. MNP-1 released the maximum heating power, reaching 330 W/g at the highest frequency, in the high side of reported values for spherical MNPs. In vitro cell viability assays of MNP-1 and MNP-4 against three cell lines expressing different levels of FA receptors (FR), namely, HEK (low expression), and HeLa (high expression), and HepG2 (high expression), demonstrated that they are not cytotoxic. When the cells were incubated in the presence of a 175 kHz magnetic field, a significant reduction in cell viability and clone formation was obtained for the high expressing FR cells incubated with MNP-4, suggesting that MNP-4 particles are good candidates for magnetic field hyperthermia and active targeting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza