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Comprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry Analysis of Exhaled Breath Compounds after Whole Grain Diets.
Raninen, Kaisa; Nenonen, Ringa; Järvelä-Reijonen, Elina; Poutanen, Kaisa; Mykkänen, Hannu; Raatikainen, Olavi.
Afiliación
  • Raninen K; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  • Nenonen R; SIB Labs, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  • Järvelä-Reijonen E; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  • Poutanen K; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
  • Mykkänen H; VTT Technical Research Centre of Finland, P.O. Box 1000, FI-02044 VTT Espoo, Finland.
  • Raatikainen O; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.
Molecules ; 26(9)2021 May 02.
Article en En | MEDLINE | ID: mdl-34063191
Exhaled breath is a potential noninvasive matrix to give new information about metabolic effects of diets. In this pilot study, non-targeted analysis of exhaled breath volatile organic compounds (VOCs) was made by comprehensive two-dimensional gas chromatography-mass spectrometry (GCxGC-MS) to explore compounds relating to whole grain (WG) diets. Nine healthy subjects participated in the dietary intervention with parallel crossover design, consisting of two high-fiber diets containing whole grain rye bread (WGR) or whole grain wheat bread (WGW) and 1-week control diets with refined wheat bread (WW) before both diet periods. Large interindividual differences were detected in the VOC composition. About 260 VOCs were detected from exhaled breath samples, in which 40 of the compounds were present in more than half of the samples. Various derivatives of benzoic acid and phenolic compounds, as well as some furanones existed in exhaled breath samples only after the WG diets, making them interesting compounds to study further.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Respiratorias / Fibras de la Dieta / Dieta / Compuestos Orgánicos Volátiles / Granos Enteros / Cromatografía de Gases y Espectrometría de Masas Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Respiratorias / Fibras de la Dieta / Dieta / Compuestos Orgánicos Volátiles / Granos Enteros / Cromatografía de Gases y Espectrometría de Masas Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Suiza