Effects of Age, Level of Education and HIV Status on Cognitive Performance in West African Older Adults: The West Africa IeDEA Cohort Collaboration.

Bernard, C; Font, H; Diallo, Z; Ahonon, R; Tine, J M; Abouo, F N; Tanon, A; Messou, E; Seydi, M; Dabis, F; Dartigues, J-F; de Rekeneire, N

Bernard, C; Font, H; Diallo, Z; Ahonon, R; Tine, J M; Abouo, F N; Tanon, A; Messou, E; Seydi, M; Dabis, F; Dartigues, J-F; de Rekeneire, N.

Afiliación

Bernard C; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, 33000, Bordeaux, France. charlotte.bernard@u-bordeaux.fr.
Font H; Univ. Bordeaux, ISPED, Bordeaux Population Health Research Center, UMR 1219, 33000, Bordeaux, France. charlotte.bernard@u-bordeaux.fr.
Diallo Z; , BORDEAUX Cedex, France. charlotte.bernard@u-bordeaux.fr.
Ahonon R; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, 33000, Bordeaux, France.
Tine JM; Univ. Bordeaux, ISPED, Bordeaux Population Health Research Center, UMR 1219, 33000, Bordeaux, France.
Abouo FN; Service de maladies infectieuses et tropicales, CHU Treichville, Abidjan, Côte d'Ivoire.
Tanon A; Centre de prise en charge de recherche et de formation (CePReF), Yopougon Attié Hospital, Abidjan, Côte d'Ivoire.
Messou E; Service de maladies infectieuses et tropicales, CRCF, CHNU de Fann, Dakar, Senegal.
Seydi M; Service de maladies infectieuses et tropicales, CHU Treichville, Abidjan, Côte d'Ivoire.
Dabis F; Service de maladies infectieuses et tropicales, CHU Treichville, Abidjan, Côte d'Ivoire.
Dartigues JF; Centre de prise en charge de recherche et de formation (CePReF), Yopougon Attié Hospital, Abidjan, Côte d'Ivoire.
de Rekeneire N; Service de maladies infectieuses et tropicales, CRCF, CHNU de Fann, Dakar, Senegal.

AIDS Behav ; 25(10): 3316-3326, 2021 Oct.

Article en En | MEDLINE | ID: mdl-34050826

RESUMEN

An in-depth understanding of the impact of aging, cognitive reserve, and HIV status on cognitive function is needed in older West African adults. Ninety-nine HIV-negative and 334 HIV-positive adults aged ≥ 50 years were enrolled in three clinics (Senegal and Côte d'Ivoire) participating in the IeDEA West Africa collaboration. All subjects underwent the Free and Cued Selective Reminding Test (FCSRT) and the Isaacs Set Test (IST). Age (both linear and quadratic), education level, and HIV status effects on Z-scores were assessed using multivariate linear regression models. Interactions between HIV status and age or educational level were tested. In the present cohort of older West African adults, the role of age and educational level on episodic memory and verbal fluency was observed without revealing an interaction between HIV status and age effect. As age had quadratic effects, older HIV-positive adults should not be considered as a unique group irrespective of their age. Low-educated HIV-positive patients had the lowest verbal fluency performance compared to others. Further studies are needed to duplicate these results. In clinical settings, screening and adapted programs focusing on improving cognition in those patients are needed.

Asunto(s)

Infecciones por VIH; Anciano; Cognición; Estudios de Cohortes; Côte d'Ivoire/epidemiología; Escolaridad; Infecciones por VIH/epidemiología; Humanos

Palabras clave

Aging; Cognition; Education level; HIV status; West Africa

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: Africa Idioma: En Revista: AIDS Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos

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