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Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Robbins, Jeremy M; Peterson, Bennet; Schranner, Daniela; Tahir, Usman A; Rienmüller, Theresa; Deng, Shuliang; Keyes, Michelle J; Katz, Daniel H; Beltran, Pierre M Jean; Barber, Jacob L; Baumgartner, Christian; Carr, Steven A; Ghosh, Sujoy; Shen, Changyu; Jennings, Lori L; Ross, Robert; Sarzynski, Mark A; Bouchard, Claude; Gerszten, Robert E.
Afiliación
  • Robbins JM; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Peterson B; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Schranner D; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Tahir UA; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Rienmüller T; Exercise Biology Group, Faculty of Sports and Health Sciences, Technical University of Munich, Munich, Germany.
  • Deng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Keyes MJ; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Katz DH; Institute of Health Care Engineering with Testing Center of Medical Devices, Graz University of Technology, Graz, Austria.
  • Beltran PMJ; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Barber JL; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Baumgartner C; National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
  • Carr SA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Ghosh S; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Shen C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Jennings LL; Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
  • Ross R; Institute of Health Care Engineering with Testing Center of Medical Devices, Graz University of Technology, Graz, Austria.
  • Sarzynski MA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bouchard C; Cardiovascular & Metabolic Disorders Program and Center for Computational Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Gerszten RE; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nat Metab ; 3(6): 786-797, 2021 06.
Article en En | MEDLINE | ID: mdl-34045743
Maximal oxygen uptake (VO2max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO2max, and of increases of VO2max in response to exercise training (ΔVO2max), are largely unknown. Here, we measure ~5,000 plasma proteins using an affinity-based platform in over 650 sedentary adults before and after a 20-week endurance-exercise intervention and identify 147 proteins and 102 proteins whose plasma levels are associated with baseline VO2max and ΔVO2max, respectively. Addition of a protein biomarker score derived from these proteins to a score based on clinical traits improves the prediction of an individual's ΔVO2max. We validate findings in a separate exercise cohort, further link 21 proteins to incident all-cause mortality in a community-based cohort and reproduce the specificity of ~75% of our key findings using antibody-based assays. Taken together, our data shed light on biological pathways relevant to cardiorespiratory fitness and highlight the potential additive value of protein biomarkers in identifying exercise responsiveness in humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Sanguíneas / Proteoma / Proteómica / Capacidad Cardiovascular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Metab Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Sanguíneas / Proteoma / Proteómica / Capacidad Cardiovascular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Metab Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania