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Impact of age, sex and ethnicity on intra-cardiac flow components and left ventricular kinetic energy derived from 4D flow CMR.
Zhao, Xiaodan; Tan, Ru-San; Garg, Pankaj; Chai, Ping; Leng, Shuang; Bryant, Jennifer; Teo, Lynette L S; Ong, Ching Ching; Geest, Rob J van der; Allen, John C; Yip, James W; Tan, Ju Le; Plein, Sven; Westenberg, Jos J W; Zhong, Liang.
Afiliación
  • Zhao X; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
  • Tan RS; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; Duke-NUS Medical School, National University of Singapore, 8 College Road, 169857, Singapore.
  • Garg P; University of Sheffield, C Floor, Royal Hallamshire Hospital, Sheffield, United Kingdom.
  • Chai P; National University Hospital Singapore, 5 Lower Kent Ridge Rd, 119074, Singapore.
  • Leng S; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
  • Bryant J; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore.
  • Teo LLS; National University Hospital Singapore, 5 Lower Kent Ridge Rd, 119074, Singapore.
  • Ong CC; National University Hospital Singapore, 5 Lower Kent Ridge Rd, 119074, Singapore.
  • Geest RJV; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
  • Allen JC; Duke-NUS Medical School, National University of Singapore, 8 College Road, 169857, Singapore.
  • Yip JW; National University Hospital Singapore, 5 Lower Kent Ridge Rd, 119074, Singapore.
  • Tan JL; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; Duke-NUS Medical School, National University of Singapore, 8 College Road, 169857, Singapore.
  • Plein S; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
  • Westenberg JJW; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
  • Zhong L; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; Duke-NUS Medical School, National University of Singapore, 8 College Road, 169857, Singapore. Electronic address: zhong.liang@nhcs.com.sg.
Int J Cardiol ; 336: 105-112, 2021 08 01.
Article en En | MEDLINE | ID: mdl-34044022
BACKGROUND: Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) allows quantification of left ventricular (LV) blood flow. We aimed to 1) establish reference ranges for 4D flow CMR-derived LV relative flow components and kinetic energy parameters indexed to end-diastolic volume (KEiEDV) among healthy Asian subjects, 2) assess effects of age and sex on these parameters, and 3) compare these parameters between Asian and Caucasian subjects. METHODS: 74 healthy Asian subjects underwent cine and 4D flow CMR. Relative flow components (direct flow, retained inflow, delayed ejection flow, residual volume) and multiple phasic KEiEDV (LV global, peak systolic, systolic, diastolic, peak E-wave, peak A-wave) were analyzed. Sex- and age-specific reference ranges were reported. RESULTS: Relative flow components and systolic phase KEiEDV did not vary with age. Women had higher retained inflow and peak E-wave KEiEDV, lower residual volume, peak systolic and systolic KEiEDV than men. Peak A-wave KEiEDV increased significantly (r = 0.474) whereas peak E-wave KEiEDV (r = -0.458) and E-wave/A-wave ratio (r = -0.528) decreased with age. A sub-population (n = 44) was compared with 44 sex- and age-matched Caucasian subjects: no significant group differences were observed for all 4D flow CMR parameters. CONCLUSION: Asian sex- and age-specific 4D flow CMR reference ranges were established. Sex differences in retained inflow, residual volume, peak systolic, systolic KEiEDV and peak E-wave KEiEDV were observed. Ageing influenced diastolic KEiEDV but not systolic phase KEiEDV or relative flow components. All studied parameters were similar between sex- and age-matched Asian and Caucasian subjects, implying generalizability of the ranges.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interpretación de Imagen Asistida por Computador / Etnicidad Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Male Idioma: En Revista: Int J Cardiol Año: 2021 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interpretación de Imagen Asistida por Computador / Etnicidad Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Male Idioma: En Revista: Int J Cardiol Año: 2021 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos