Your browser doesn't support javascript.
loading
Acute promyelocyte leukemia arose from CALR 1 mutated post essential thrombocythemia- myelofibrosis with splanchnic vein thrombosis: A case report.
Morsia, E; Goteri, G; Torre, E; Garvey, K B; Discepoli, G; Tassoni, A; Mancini, S; Giantomassi, F; Poloni, A; Olivieri, A; Rupoli, S.
Afiliación
  • Morsia E; Clinica Ematologica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Goteri G; Anatomia Patologica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Torre E; Università Politecnica delle Marche, Ancona, Italy.
  • Garvey KB; Clinica Ematologica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Discepoli G; Clinica Ematologica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Tassoni A; Laboratorio di Genetica Medica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Mancini S; Laboratorio Clinica di Ematologia, Università Politecnica delle Marche, Ancona, Italy.
  • Giantomassi F; Laboratorio Clinica di Ematologia, Università Politecnica delle Marche, Ancona, Italy.
  • Poloni A; Anatomia Patologica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Olivieri A; Clinica Ematologica, Ospedali Riuniti di Ancona, Ancona, Italy.
  • Rupoli S; Università Politecnica delle Marche, Ancona, Italy.
Leuk Res Rep ; 15: 100243, 2021.
Article en En | MEDLINE | ID: mdl-34040959
Major disease complications for patients with essential thrombocythemia (ET) include thrombosis and fibrotic or leukemic transformation. Calreticulin (CALR) mutation type 1 frequencies in ET are estimated between 7% and 11% and ET patients carrying CALR type 1 mutation are associated with lower risk of thrombosis but higher risk of myelofibrosis transformation compared to ET patients with JAK2 mutation. Leukemic transformation rates at 20 years are estimated at less than 5% for ET and risk factors for leukemic transformation are advanced age, thrombosis history, leukocytosis, and anemia. Amongst the subtypes of blast phase myeloproliferative neoplasms, acute promyelocytic leukemia is extremely rare. Herein, we present a case of a promyelocytic blast crisis of post-ET myelofibrosis with associated life-threatening splanchnic vein thrombosis. This case suggests that inflammation plays a key role in thrombotic events and fibrotic/leukemic transformation in ET patients, regardless the molecular landscape.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Leuk Res Rep Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Leuk Res Rep Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido