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Caffeine: cardiorespiratory effects and tissue protection in animal models.
Villanueva-García, Dina; Mota-Rojas, Daniel; Miranda-Cortés, Agatha; Ibarra-Ríos, Daniel; Casas-Alvarado, Alejandro; Mora-Medina, Patricia; Martínez-Burnes, Julio; Olmos-Hernández, Adriana; Hernández-Avalos, Ismael.
Afiliación
  • Villanueva-García D; Division of Neonatology, National Institute of Health, Hospital Infantil de México Federico Gómez, Doctor Márquez 162, 06720, Mexico City, Mexico.
  • Mota-Rojas D; Neurophysiology, Behavior, and Animal Welfare Assessment, Department of Animal Production and Agriculture (DPAA), Universidad Autónoma Metropolitana (UAM) Xochimilco Campus, Calzada del Hueso 1100. Col. Villa Quietud. Coyoacán, 04960, Mexico City, Mexico.
  • Miranda-Cortés A; Clinical Pharmacology and Veterinary Anaesthesia, Department of Biological Science, FESC, Universidad Nacional Autónoma de México (UNAM), Carretera Cuautitlán-Teoloyucan Km. 2.5 San Sebastian Xhala, 54714, Cuautitlán Izcalli, State of Mexico, Mexico.
  • Ibarra-Ríos D; Division of Neonatology, National Institute of Health, Hospital Infantil de México Federico Gómez, Doctor Márquez 162, 06720, Mexico City, Mexico.
  • Casas-Alvarado A; Neurophysiology, Behavior, and Animal Welfare Assessment, Department of Animal Production and Agriculture (DPAA), Universidad Autónoma Metropolitana (UAM) Xochimilco Campus, Calzada del Hueso 1100. Col. Villa Quietud. Coyoacán, 04960, Mexico City, Mexico.
  • Mora-Medina P; Livestock Science Department, Universidad Nacional Autónoma de México (UNAM), Facultad de Estudios Superiores Cuautitlán, Carretera Cuautitlán-Teoloyucan Km. 2.5 San Sabastian Xhala, 54714, Cuautitlán Izcalli, State of Mexico, Mexico.
  • Martínez-Burnes J; Graduate and Research Department, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tamaulipas, Km 5 Carretera Victoria-Mante, 87000, Cd. Victoria, Tamaulipas, Mexico.
  • Olmos-Hernández A; Division of Biotechnology, Department Bioterio and Experimental Surgery. Instituto Nacional de Rehabilitación-Luis Guillermo Ibarra Ibarra (INR-LGII), Calzada México Xochimilco, 289, 14389, Mexico City, Mexico.
  • Hernández-Avalos I; Clinical Pharmacology and Veterinary Anaesthesia, Department of Biological Science, FESC, Universidad Nacional Autónoma de México (UNAM), Carretera Cuautitlán-Teoloyucan Km. 2.5 San Sebastian Xhala, 54714, Cuautitlán Izcalli, State of Mexico, Mexico.
Exp Anim ; 70(4): 431-439, 2021 Nov 10.
Article en En | MEDLINE | ID: mdl-34039788
The aim of this review is to analyze the cardiorespiratory and tissue-protective effects of caffeine in animal models. Peer-reviewed literature published between 1975 and 2021 was retrieved from CAB Abstracts, PubMed, ISI Web of Knowledge, and Scopus. Extracted data were analyzed to address the mechanism of action of caffeine on cardiorespiratory parameters (heart rate and rhythm), vasopressor effects, and some indices of respiratory function; we close this review by discussing the current debate on the research carried out on the effects of caffeine on tissue protection. Adenosine acts through specific receptors and is a negative inotropic and chronotropic agent. Blockage of its cardiac receptors can cause tachycardia (with arrhythmogenic potential) due to the intense activity of ß1 receptors. In terms of tissue protection, caffeine inhibits hyperoxia-induced pulmonary inflammation by decreasing proinflammatory cytokine expression in animal models. The protection that caffeine provides to tissues is not limited to the CNS, as studies have demonstrated that it generates attenuation of inflammatory effects in pulmonary tissue. It inhibits the effects of some pro-inflammatory cytokines and prevents functional and structural changes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Función Respiratoria / Cafeína / Sustancias Protectoras / Frecuencia Cardíaca Límite: Animals Idioma: En Revista: Exp Anim Asunto de la revista: MEDICINA VETERINARIA Año: 2021 Tipo del documento: Article País de afiliación: México Pais de publicación: Japón
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Función Respiratoria / Cafeína / Sustancias Protectoras / Frecuencia Cardíaca Límite: Animals Idioma: En Revista: Exp Anim Asunto de la revista: MEDICINA VETERINARIA Año: 2021 Tipo del documento: Article País de afiliación: México Pais de publicación: Japón