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The Indigenous South American Tsimane Exhibit Relatively Modest Decrease in Brain Volume With Age Despite High Systemic Inflammation.
Irimia, Andrei; Chaudhari, Nikhil N; Robles, David J; Rostowsky, Kenneth A; Maher, Alexander S; Chowdhury, Nahian F; Calvillo, Maria; Ngo, Van; Gatz, Margaret; Mack, Wendy J; Law, E Meng; Sutherland, M Linda; Sutherland, James D; Rowan, Christopher J; Wann, L Samuel; Allam, Adel H; Thompson, Randall C; Michalik, David E; Cummings, Daniel K; Seabright, Edmond; Alami, Sarah; Garcia, Angela R; Hooper, Paul L; Stieglitz, Jonathan; Trumble, Benjamin C; Gurven, Michael D; Thomas, Gregory S; Finch, Caleb E; Kaplan, Hillard.
Afiliación
  • Irimia A; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Chaudhari NN; Corwin D. Denney Research Center, Department of Biomedical Engineering, University of Southern California, Los Angeles, USA.
  • Robles DJ; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Rostowsky KA; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Maher AS; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Chowdhury NF; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Calvillo M; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Ngo V; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Gatz M; Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA.
  • Mack WJ; Center for Economic and Social Research, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, USA.
  • Law EM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Sutherland ML; iBRAIN Research Laboratory, Departments of Neuroscience, Computer Systems and Electrical Engineering, Monash University, Melbourne, Victoria, Australia.
  • Sutherland JD; Department of Radiology, The Alfred Health Hospital, Melbourne, Victoria, Australia.
  • Rowan CJ; Department of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, USA.
  • Wann LS; MemorialCare Heart & Vascular Institute, Fountain Valley, California, USA.
  • Allam AH; MemorialCare Heart & Vascular Institute, Fountain Valley, California, USA.
  • Thompson RC; Renown Institute for Heart and Vascular Health, Reno, Nevada, USA.
  • Michalik DE; School of Medicine, University of Nevada, Reno, USA.
  • Cummings DK; Ascension Healthcare, Milwaukee, Wisconsin, USA.
  • Seabright E; Department of Cardiology, School of Medicine, Al-Azhar University, Al Mikhaym Al Daem, Cairo, Egypt.
  • Alami S; Saint Luke's Mid America Heart Institute, University of Missouri, Kansas City, USA.
  • Garcia AR; Department of Pediatrics, School of Medicine, University of California at Irvine, Orange, USA.
  • Hooper PL; MemorialCare Miller Children's & Women's Hospital, Long Beach Medical Center, California, USA.
  • Stieglitz J; Department of Anthropology, University of New Mexico, Albuquerque, USA.
  • Trumble BC; Economic Science Institute, Argyros School of Business and Economics, Chapman University, Orange, California, USA.
  • Gurven MD; Department of Anthropology, University of New Mexico, Albuquerque, USA.
  • Thomas GS; Department of Anthropology, University of California, Santa Barbara, USA.
  • Finch CE; Center for Evolution & Medicine, School of Human Evolution and Social Change, Arizona State University, Tempe, USA.
  • Kaplan H; Department of Anthropology, University of New Mexico, Albuquerque, USA.
J Gerontol A Biol Sci Med Sci ; 76(12): 2147-2155, 2021 11 15.
Article en En | MEDLINE | ID: mdl-34038540
Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. Despite a high infectious disease burden, Tsimane forager-horticulturists of Bolivia have the lowest prevalence of coronary atherosclerosis of any studied population and present few cardiovascular disease (CVD) risk factors despite a high burden of infections and therefore inflammation. This study (a) examines the statistical association between brain volume (BV) and age for Tsimane and (b) compares this association to that of 3 industrialized populations in the United States and Europe. This cohort-based panel study enrolled 746 participants aged 40-94 (396 males), from whom computed tomography (CT) head scans were acquired. BV and intracranial volume (ICV) were calculated from automatic head CT segmentations. The linear regression coefficient estimate ß^T of the Tsimane (T), describing the relationship between age (predictor) and BV (response, as a percentage of ICV), was calculated for the pooled sample (including both sexes) and for each sex. ß^T was compared to the corresponding regression coefficient estimate ß^R of samples from the industrialized reference (R) countries. For all comparisons, the null hypothesis ß T = ß R was rejected both for the combined samples of males and females, as well as separately for each sex. Our results indicate that the Tsimane exhibit a significantly slower decrease in BV with age than populations in the United States and Europe. Such reduced rates of BV decrease, together with a subsistence lifestyle and low CVD risk, may protect brain health despite considerable chronic inflammation related to infectious burden.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Encéfalo / Inflamación / Estilo de Vida Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Bolivia Idioma: En Revista: J Gerontol A Biol Sci Med Sci Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Encéfalo / Inflamación / Estilo de Vida Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Bolivia Idioma: En Revista: J Gerontol A Biol Sci Med Sci Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos