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Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy.
Cao, Shoupeng; Xia, Yifeng; Shao, Jingxin; Guo, Beibei; Dong, Yangyang; Pijpers, Imke A B; Zhong, Zhiyuan; Meng, Fenghua; Abdelmohsen, Loai K E A; Williams, David S; van Hest, Jan C M.
Afiliación
  • Cao S; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
  • Xia Y; Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
  • Shao J; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
  • Guo B; Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
  • Dong Y; Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
  • Pijpers IAB; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
  • Zhong Z; Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
  • Meng F; Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
  • Abdelmohsen LKEA; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
  • Williams DS; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
  • van Hest JCM; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
Angew Chem Int Ed Engl ; 60(32): 17629-17637, 2021 08 02.
Article en En | MEDLINE | ID: mdl-34036695
Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features of loading capacity, emission brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles. The presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability, which improves the efficiency of co-encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo. This contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Polietilenglicoles / Fármacos Fotosensibilizantes / Plásticos Biodegradables / Colorantes Fluorescentes / Antineoplásicos Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Polietilenglicoles / Fármacos Fotosensibilizantes / Plásticos Biodegradables / Colorantes Fluorescentes / Antineoplásicos Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania