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Response to first dose of inhaled albuterol in mechanically ventilated preterm infants.
Raffay, Thomas M; Brasher, Mandy; Place, Brooke C; Patwardhan, Abhijit; Giannone, Peter J; Bada, Henrietta; Westgate, Philip M; Abu Jawdeh, Elie G.
Afiliación
  • Raffay TM; Pediatrics/Neonatology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
  • Brasher M; Pediatrics/Neonatology, University of Kentucky, Lexington, KY, USA.
  • Place BC; Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
  • Patwardhan A; Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
  • Giannone PJ; Pediatrics/Neonatology, University of Kentucky, Lexington, KY, USA.
  • Bada H; Pediatrics/Neonatology, University of Kentucky, Lexington, KY, USA.
  • Westgate PM; Biostatistics, University of Kentucky, Lexington, KY, USA. philip.westgate@uky.edu.
  • Abu Jawdeh EG; Pediatrics/Neonatology, University of Kentucky, Lexington, KY, USA. elie.abujawdeh@uky.edu.
J Perinatol ; 41(7): 1704-1710, 2021 07.
Article en En | MEDLINE | ID: mdl-34035457
BACKGROUND: Bronchodilator responses among preterm infants are heterogeneous. Bedside measurements may identify responders. STUDY DESIGN: Respiratory measurements (Resistance, Compliance, FiO2) and pulse oximetry (SpO2) patterns were downloaded from infants <30 weeks gestational age during the first 2 months of life. Mechanically ventilated infants who received albuterol were included (n = 33). Measurements were compared before and after first albuterol. Secondary analyses assessed subsequent doses. RESULTS: Median gestation and birthweight were 25 3/7 weeks and 730 g, respectively. Mean Resistance decreased post-albuterol (p = 0.007). Sixty-eight percent of infants were responders based on decreased Resistance. Compliance and FiO2 did not significantly differ. Percent time in hypoxemia (SpO2 < 85%) decreased post albuterol (p < 0.02). In responders, Resistance changes diminished with subsequent administration (all p = 0.01). CONCLUSIONS: Ventilator resistance decreased in two-thirds of preterm infants, consistent with studies that utilized formal pulmonary function testing. Albuterol had a variable effect on delivered FiO2; however, hypoxemia may be useful in evaluating albuterol response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Respiración Artificial / Albuterol Tipo de estudio: Prognostic_studies Límite: Humans / Infant / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Respiración Artificial / Albuterol Tipo de estudio: Prognostic_studies Límite: Humans / Infant / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos